【摘要】 [目的]观察不同浓度川芎溶液对蟾蜍心肌收缩力和心率的影响。[方法]采用斯氏离体蛙心灌流方法,分别用0.01、0.02和0.05 g/ml川芎溶液对离体蟾蜍心脏进行灌流;先灌注阿托品,再灌注0.04 g/ml川芎溶液,考察川芎溶液对蟾蜍离体心脏心肌收缩力和心率的影响。[结果]灌注不同浓度的川芎溶液,蟾蜍心脏收缩力下降程度不同,其中0.01 g/ml川芎溶液灌注下的心脏收缩力与正常任氏液灌注下的心脏收缩力在统计学意义上差异不显著,0.02和0.05 g/ml川芎溶液灌注下的蟾蜍心脏收缩力与正常任氏液灌注下的心脏收缩力在差异显著(P<0.01);而当先注入阿托品再注入0.04 g/ml川芎溶液,蟾蜍心脏收缩力不再下降。[结论]川芎溶液能降低离体蟾蜍心脏的收缩力,其作用机制可能与细胞表面的M型受体有关。更多还原

【Abstract】 [Objective] To investigate effect of RHIZOMA CHUANXIONG on the myocardial contractility and heart rate of toad.[Method] The toads were given 0.01,0.0 and 0.05 g/ml RHIZOMA CHUANXIONG solution respectively;in addition,the toads were given 0.04 g/ml of RHIZOMA CHUANXIONG solution after infusion of atropine,investigating effect of RHIZOMA CHUANXIONG on the myocardial contractility and heart rate of toad.[Result] Effect of RHIZOMA CHUANXIONG solution of 0.02 and 0.05 g/ml on myocardial contractility and heart rate of toad was significant(P<0.01),which was different from that of 0.01 g/ml.When given atropine firstly,toad given 0.04 g/ml of RHIZOMA CHUANXIONG solution was not decreased in myocardial contractility.[Conclusion] RHIZOMA CHUANXIONG solution could reduce the myocardium of toad heart,the mechanism of which might be concerned with M receptor.更多还原