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茶叶中EGCG对高脂大鼠的降脂作用研究

Study on Effects of Epigallocatechin Gallate in Tea on Decreasing Blood Lipid of High-lipid Rats

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【作者】 王贤波周健成浩赵芸

【Author】 WANG Xian-bo et al(Laboratorial Center,Hangzhou Institute of Agricultural Sciences,Hangzhou,Zhejiang 310024)

【机构】 浙江省杭州市农业科学研究院实验中心中国农业科学研究院茶叶研究所

【摘要】 [目的]研究表没食子儿茶素没食子酸酯(EGCG)对高脂大鼠血脂调节作用。[方法]采用高脂大鼠模型,设正常对照组(Ⅰ组,喂基础饲料)、模型对照组(Ⅱ组,喂高脂饲料)、试验组(Ⅲ、Ⅳ组,喂高脂饲料,并每日分别灌喂0.5、1.0 g/kg的EGCG),连续喂饲30 d,测定其血清中TC、TG、HDL-C和LDL-C含量。[结果]Ⅲ、Ⅳ试验组TC、LDL-C含量极显著低于Ⅱ组(P<0.01);Ⅲ、Ⅳ组TG含量显著低于Ⅱ组(P<0.05);Ⅲ、Ⅳ组HDL-C含量较Ⅱ组变化不明显;Ⅳ组HDL-C含量略有升高,但差异不显著;Ⅲ、Ⅳ组AI值极显著低于Ⅱ组(P<0.01)。[结论]EGCG具有降血脂作用。

【Abstract】 [Objective] To study the decreasing blood lipid effect of epigallocatechin gallate(EGCG) in high-lipid rats.[Method] Using high-lipid rats model,four groups were subdivided including normal CK(Ⅰ,feeding normal diet),model CK(Ⅱ,feeding high-fat diet) and test group(Ⅲ,Ⅳ,feeding high fat diet and giving EGCG of 0.5 and 1.0 g/kg,respectively).The rats in the four groups all were given for 30 d and were determined content of TC,TG,HDL-C and LDL-C in serum.[Result] Contents of TC and LDL-C in rats tested in group Ⅲ and Ⅳ were highly significantly lower than those in group Ⅱ(P<0.01);TG in group Ⅲ and Ⅳ was significantly lower than that in group Ⅱ(P<0.05).HDL-C in group Ⅲ and Ⅳ did not vary significantly in comparison with group Ⅱ and rats in group Ⅳ were a little higher in HDL-C.Compared with group Ⅱ,rats in group Ⅲ and Ⅳ were highly lower in AI value(P<0.01).[Conclusion] EGCG is provided with effect of reducing blood lipid.

【关键词】 EGCG高脂大鼠降血脂
【Key words】 EGCGHigh-lipid ratReducing blood lipid
【基金】 杭州市农业科技攻关项目(20091832B05)
  • 【文献出处】 安徽农业科学 ,Journal of Anhui Agricultural Sciences , 编辑部邮箱 ,2011年18期
  • 【分类号】R285.5
  • 【被引频次】16
  • 【下载频次】221
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