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卵泡液中Inhibin B与IVF-ET的相关性

Relationships between inhibin B in follicle fluild and IVF-ET results

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【作者】 张文杰冯玉昆杨晓花

【Author】 ZHANG Wen-jie1,FENG Yu-kun2,et al.(1.Shanxi Maternity and Child Health Care Hospital,Xian 710003;2.The First Affiliated Hospital Of Kunming Medical University Kunming 650032)

【机构】 陕西省妇幼保健院昆明医学院第一附属医院

【摘要】 目的探讨卵泡液中抑制素B(Inhibin B)与体外受精-胚胎移植(In-vitro fertilization and embryo transfer,IVF-ET)结局的关系及规律。评价其在IVF-ET过程中对卵子受精、胚胎发育、妊娠结局的作用及临床应用价值。方法对38例输卵管和男性因素不孕症患者进行IVF-ET,检测卵泡液中Inhibin B的含量;分析卵泡液中Inhibin B的含量与获卵数、优质胚胎形成率、妊娠结局的关系。结果卵泡液中Inhibin B的值与获卵数(r=0.455,P<0.05)、E2(r=0.529,P<0.05)、胚胎质量(r=0.405,P<0.05)呈正相关;与年龄(r=-0.445,P<0.05)呈负相关;在妊娠组卵泡液中含量明显高于非妊娠组(P<0.05)结论卵泡液中Inhibin B含量可以作为预测妊娠结局的指标。

【Abstract】 Objective:The aim of this study was to measure concentrations of Inhibin B in follicular fluid(FF) of women undergoing to in vitro fertilization-embryo transfer(IVF-ET) and to research the relationship between Inhibin B and In-vitro fertilization and embryo transfer(IVF-ET) results.Methods:Follicular fluid was collected from patients undergoing oocyte retrieval of IVF ET.All patients consisted of 38 tubal and male factor.The levels of Inhibin B were measured.These parameters were compared between the pregnant group and no pregnant group.The correlation between the levels of Inhibin B and the quality of subsequent embryo development were investigated.Results:The levels of Inhibin B in FF was positively correlated with the numbers of retrivaled oocyte,E2,embryo quality(P < 0.05) and inversely correlated with age(P < 0.05).It was found significantly higher in pregnant group than no pregnant group(P < 0.05).Conclusions:The levels of Inhibin B in FF are markers of the embryo quality and pregency outcome.

  • 【文献出处】 中国优生与遗传杂志 ,Chinese Journal of Birth Health & Heredity , 编辑部邮箱 ,2010年08期
  • 【分类号】R714.8
  • 【被引频次】4
  • 【下载频次】110
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