【摘要】 目的探讨卵泡液中抑制素B(Inhibin B)与体外受精-胚胎移植(In-vitro fertilization and embryo transfer,IVF-ET)结局的关系及规律。评价其在IVF-ET过程中对卵子受精、胚胎发育、妊娠结局的作用及临床应用价值。方法对38例输卵管和男性因素不孕症患者进行IVF-ET,检测卵泡液中Inhibin B的含量;分析卵泡液中Inhibin B的含量与获卵数、优质胚胎形成率、妊娠结局的关系。结果卵泡液中Inhibin B的值与获卵数(r=0.455,P<0.05)、E2(r=0.529,P<0.05)、胚胎质量(r=0.405,P<0.05)呈正相关;与年龄(r=-0.445,P<0.05)呈负相关;在妊娠组卵泡液中含量明显高于非妊娠组(P<0.05)结论卵泡液中Inhibin B含量可以作为预测妊娠结局的指标。更多还原

【Abstract】 Objective:The aim of this study was to measure concentrations of Inhibin B in follicular fluid(FF) of women undergoing to in vitro fertilization-embryo transfer(IVF-ET) and to research the relationship between Inhibin B and In-vitro fertilization and embryo transfer(IVF-ET) results.Methods:Follicular fluid was collected from patients undergoing oocyte retrieval of IVF ET.All patients consisted of 38 tubal and male factor.The levels of Inhibin B were measured.These parameters were compared between the pregnant group and no pregnant group.The correlation between the levels of Inhibin B and the quality of subsequent embryo development were investigated.Results:The levels of Inhibin B in FF was positively correlated with the numbers of retrivaled oocyte,E2,embryo quality(P < 0.05) and inversely correlated with age(P < 0.05).It was found significantly higher in pregnant group than no pregnant group(P < 0.05).Conclusions:The levels of Inhibin B in FF are markers of the embryo quality and pregency outcome.更多还原