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TGF-β1与EGFR在子宫内膜癌患者内膜组织中的表达及意义

The expression and meaning of TGF-β1 and EGFR in endometrial carcinoma

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【作者】 王卓然宋巍孙壮状范佳颖关咏梅

【Author】 WANG Zhuo-ran,SONG Wei,SUN Zhuang-zhuang,FAN Jia-ying,GUAN Yong-mei. (The Asisted Reproduction Department,the First Affiliated Hospital of Harbin Medical University,Harbin,150001,China)

【机构】 哈尔滨医科大学附属第一医院生殖医学科

【摘要】 目的检测转化生长因子-β1(transforming growth factor beta 1,TGF-β1)以及表皮生长因子受体(epider-mal growth factor receptor,EGFR)在子宫内膜癌患者内膜组织中的表达,探讨两者在子宫内膜癌发生发展中的作用,为分子靶向治疗提供理论依据。方法采用免疫组织化学方法检测子宫内膜癌组(26例)及正常子宫内膜组(26例)中TGF-β1和EGFR的表达情况。结果 TGF-β1在子宫内膜癌组中的表达显著高于正常子宫内膜组(P<0.05);EGFR在子宫内膜癌组中的表达也显著高于正常子宫内膜组(P<0.05)。结论 TGF-β1及EGFR的异常表达可能与子宫内膜癌的发生发展有关。

【Abstract】 Objective:To study the expression of transforming growth factor beta 1 (TGF-β1) and epidermal growth factor receptor (EGFR) in endometrial carcinoma,to explore the role of TGF-β1 and EGFR in the pathogenesis of endometrial carcinoma and provide a theoretical basis for molecular targeted therapy. Methods:Immunohistochemical streptavidin peroxidase method wasused to detect the expression of TGF-β1 and EGFR in the endometrial carcinoma of26 cases and in the normal endometrium of 26 ca-ses. Results:The expression of TGF-β1 in endometrial carcinoma were significantly higher than that in normal endometrium (P<0.05); The expression of EGFR in endometrial carcinoma were significantly higher than that in normal endometrium (P<0.05).Conclusion:The abnormal expression of TGF-β1 and EGFR might be correlation with the pathogenesis of endometrial carcinoma.

  • 【文献出处】 中国优生与遗传杂志 ,Chinese Journal of Birth Health & Heredity , 编辑部邮箱 ,2010年07期
  • 【分类号】R737.33
  • 【被引频次】9
  • 【下载频次】217
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