【摘要】 目的研究肉苁蓉提取物对败血症大鼠急性肺损伤(ALI)的影响。方法采用盲肠结扎穿孔术复制败血症模型,观察肺组织病理学变化,测定ALI生物学指标。结果生理盐水组肺间质水肿,肺泡腔内可见大量细胞浸润和血浆蛋白渗出,肺血管内皮细胞损伤。肺湿/干重比、肺泡灌洗液中中性粒细胞比例、蛋白含量及肺泡通透指数(LPI)、肺毛细血管通透性(PVP)均显著升高。肺组织丙二醛(MDA)、超氧化物歧化酶(SOD)、髓过氧化物酶(MPO)均显著升高。上述指标肉苁蓉组均较生理盐水组显著下降。结论肉苁蓉对败血症大鼠ALI具有良好保护作用,其机制可能是通过抑制中性粒细胞在肺组织的浸润,减少氧自由基对肺组织损伤实现的。更多还原

【Abstract】 Objective:To study the effect of Cistanche deserticola on acute lung injury(ALI) in rats with sepsis.Methods:The model of sepsis was made by cecal ligation and puncture.The histopathological examinations were performed and the biological markers of ALI were measured.Results:Under light microscope in the saline group,there were edema of lung interspace,large amount of erythrocytes and neutrophils and plasma protein in the alveolar cavities.The lung wet/dry weight,the rate of neutrophils and the protein content in the pulmonary alveolar lavage fluid pulmonary vascular permeability and pulmonary alveolar permeability and MDA,SOD,as well as MPO were correspondingly significantly increased.In the group with Cistanche deserticola treatment,these indices of ALI were significantly lower than those in the group with saline.Conclusion:Cistanche deserticola has great effects on ALI in rats with sepsis.The therapeutic mechanism is possibly though the inhibition of neutrophils and oxidative free radical.更多还原