【摘要】 目的探讨急性白血病患者化疗后应用白介素-2治疗对细胞免疫功能的影响及其临床意义。方法将79例急性白血病患者随机分为两组,化疗加白介素-2组(治疗组)40例和单纯化疗组(对照组)39例,治疗组于化疗后第1天加用白介素-2 40万U静脉滴注,连用14 d;对照组单用常规化疗,化疗前后均未予白介素-2治疗。检测化疗前及治疗后T淋巴细胞亚群的变化。结果治疗后14 d,治疗组的CD4~+、CD4~+/CD8~+水平明显高于对照组(P<0.05),化疗后白细胞谷值、中性粒细胞谷值,对照组明显低于治疗组(P<0.05)。结论白介素-2能明显提高患者化疗后CD4~+、CD4~+/CD8~+水平,从而改善接受化疗机体的免疫状态。白介素-2对急性白血病化疗后骨髓抑制具有防治作用。更多还原

【Abstract】 Objective To probe into the influence and the clincal signicance of using interieukin -2 to T lymphocyte subgroup after patients’chemotherapy for leukmia patients.Methods Comparing with two groups:a treating group(chemotheraphy with Interieukin - 2) and a control group(pure chemotherapy).The treating group,after the chemotherapy,are dripped with interieukin -2(400 000 U) for 14 days.Then examine the T lymphocyte change in pre - chemotherapy and post - chemotherapy.Results After 14 days,the CD4~+,CD4~+ /CD8~+ levels in serum of the patients receiving the combined therapy were much higher than those of the patients receiving chemotherapy only(P < 0.05).The average values of the lowest WBC and ANC counts in the 40 cases of treatment group after chemotherapy,the control group were lower than the treatment group(P < 0.05).Conclusion Interieukin - 2 can significantly improve CD4~+、CD4~+ /CD8~+ levels in serum of the patients after chemotherapy,therefore,it can improve the immune state of these patients.Interieukin - 2 can be used as preventive and therapeutic agent in bone marrow depression caused by chemotherapy in acute leukemia.更多还原