【摘要】 目的评价血清胱抑素C在糖尿病患者肾损伤早期发生中的作用及意义。方法应用全自动生化分析仪采用免疫比浊法测定40例糖尿病患者和40例的血清Cys-C、BUN、Cr的浓度,并把糖尿病组与对照组的结果进行比较。结果糖尿病组的检测结果为Cys-C(1.41±0.67)mg/L、BUN(6.24±3.74)mmol/L、Cr(79.25±55.07)μmol/L,而正常对照组为Cys-C(0.92±0.21)mg/L、BUN(4.89±4.36)mmol/L、Cr(74.05±90.92)μmol/L。糖尿病组中Cys-C、BUN和Cr阳性数分别为18例(45.0%)、6例(15.0%)、4例(10.0%)。糖尿病组较正常对照组的检测结果明显增高,差异有统计学意义(P<0.01)。结论糖尿病患者血清中Cys-C有明显改变,Cys-C在反映糖尿病肾损害方面比Cr、BUN优越,值得在临床上推广应用。更多还原

【Abstract】 Objective To study the early diagnostic value of serum cystatin C for the patients with diabetes mellitus. Methods The serum Cys - C,Scr and BUN level were measured and comparatived in 40 patients who had steady - state diabetes with early renal impairments and 40 health controls patients,according to the detecting of RILI 7060.Results The results of the patients with diabetes mellitus were Cys-C(1.41±0.67),BUN(6.24±3.74),Cr(79.25±55.07),the results of health controls were Cys - C(0.92±0.21),BUN(4.89±4.36),Cr(74.05±90.92),The serum Cys - C level in patients with period diabetes mellitus was significantly higher than that in health controls,the masculine rates of Cys - C,BUN and Cr in patients who had steady - state diabetes with early renal impairment were 18(0.45),6(0.15),4(0.10).Conclusion Serum Cystatin C has inportant diagnostic value for the patients with diabetes mellitus.更多还原