【摘要】 目的:观察复方丹参滴丸对冠心病患者冠状动脉介入治疗(PCI)后血液流变学的影响,探讨复方丹参滴丸治疗冠心病的临床实用价值。方法:选择确诊冠心病行PCI治疗的患者160例,随机分为治疗组(n=83)和对照组(n=77),对照组于PCI后给予常规用药,包括阿司匹林和氯吡格雷,而治疗组在此基础上,加用复方丹参滴丸口服,于术前和术后3个月,检测并分析其血液流变学指标。结果:与治疗前相比,两组患者在全血粘度高切、中切和低切方面明显降低(P<0.05),且复方丹参滴丸治疗组在治疗后全血粘度低切指标下降更明显,与对照组相比P<0.05,有统计学差异;此外,治疗组在全血还原粘度、红细胞聚集和卡松曲服应力方面与治疗前相比,亦明显降低,具有统计学差异;而对照组治疗后虽有下降趋势,但未达到统计学差异。与对照组相比,复方丹参滴丸治疗组治疗后在全血还原粘度和卡松曲服应力方面水平低于对照组,具有统计学差异(P<0.05)。结论:冠心病PCI后患者在常规用药基础上加用复方丹参滴丸,可明显改善其血流动力学指标,缓解心绞痛症状,具有临床应用价值。更多还原

【Abstract】 Objective:To investigate the effect of compound Danshen drop pill(CDDP) on hemorheology after percutaneous coronary intervention(PCI) in patients with coronary heart disease(CHD).Methods: A total of 160 patients with CHD who received PCI were randomly divided into 2 groups.The patients were treated either with routine medicines,including aspirin and clopidogrel,after PCI(control,n=77),or with CDDP combined with routine medicines(n=83).The hemorheology indexes were measured before PCI and 3 months after PCI.Results: After the treatments,whole blood viscosity(including high,middle and low shear) was obviously decreased in all patients.The viscosity was lower in CDDP group than in control group(P<0.05).Also,reduced viscosity in whole blood,erythrocyte aggregation and Casson yield shear were significantly decreased after treatment in CDDP group,but not in control group.Reduced viscosity in whole blood and Casson yield shear were lower in CDDP group than in control group.Conclusion: CDDP combined with routine medicines obviously improves hemorheology after PCI,and attenuates angina pectoris in CHD patients.CDDP is important in the treatment of CHD.更多还原