【摘要】 目的:利用功能性核磁共振成像(fMRI)技术,观察静息态下抑郁症注意网络的功能连接。方法:26例符合中国精神障碍分类与诊断标准(第三版)(CCMD-3)单相抑郁症诊断标准,同时符合美国《精神障碍诊断与统计学手册》第四版(DSM-IV)重性抑郁诊断标准抑郁症住院患者及25名年龄、受教育年限匹配的健康对照者参与了静息态fMRI扫描。分别分析抑郁症患者前、后注意网络内区域相互之间低频fMRI信号波动的相关性,以观察抑郁症注意网络的功能连接。结果:与对照组相比,抑郁组双侧前扣带回与丘脑[左侧Z分:(0.58±0.10)vs.(0.64±0.06),P=0.012;右侧Z分:(0.53±0.13)vs.(0.61±0.13),P=0.025]、双侧基底神经节与丘脑[左侧Z分:(0.66±0.07)vs.(0.70±0.05),P=0.043,右侧Z分:(0.64±0.07)vs.(0.71±0.07),P=0.002]、左侧额叶皮层与前扣带回[Z分:(0.51±0.16)vs.(0.63±0.12),P=0.003]、左侧额叶皮层与基底神经节[Z分:(0.59±0.07)vs.(0.65±0.11),P=0.029]、右侧辅助运动区与基底神经节[Z分:(0.57±0.11)vs.(0.64±0.11),P=0.024]、右侧前扣带回与辅助运动区[Z分:(0.54±0.10)vs.(0.61±0.11),P=0.043]、右侧额叶皮层与辅助运动区的功能连接减低[Z分:(0.64±0.10)vs.(0.70±0.10),P=0.028]。结论:静息态抑郁症患者注意网络的功能连接存在异常,可能与抑郁症患者认知功能损害,尤其是注意力下降有关。更多还原

【Abstract】 Objective:To explore the functional connectivity of attentional network in depressions during resting-state with functional magnetic resonance imaging(fMRI).Methods:Twenty-six patients were selected according to the diagnostic criteria for depression of Chinese Classification and Diagnostic Criteria for Mental Disorders Third Edition(CCMD-3)and the Diagnostic and Statistical Manual of Mental Disorders Fourth Edition(DSM-IV).Twenty-five healthy persons were selected as controls matched for age and education.All subjects recieved the resting state fMRI scan.To observe the attentional to the function of network connectivity,the corelations of low-frequency fMRI signal in regions of anterior and posterior attentional networks were analyzed.Results:Compared with the controls,the regions of function connectivity of the attentional network in depressed group were decreased.The data was as follows respectively:the bilateral anterior cingulate and thalamus[left Z:(0.58±0.10)vs.(0.64±0.06),P=0.012;right Z:(0.53±0.13)vs.(0.61±0.13),P=0.025],the bilateral basal ganglia and thalamus[left Z:(0.66±0.07)vs.(0.70±0.05),P=0.043,right Z:(0.64±0.07)vs.(0.71±0.07),P=0.002],the left frontal cortex and anterior cingulated[Z:(0.51±0.16)vs.(0.63±0.12),P=0.003],the left frontal cortex and basal ganglia[Z:(0.59±0.07)vs.(0.65±0.11),P=0.029],the right supplementary motor area and basal ganglia[Z:(0.57±0.11)vs.(0.64±0.11),P=0.024],the right anterior cingulate and supplementary motor area[Z:(0.54±0.10)vs.(0.61±0.11),P=0.043],the right frontal cortex and supplementary motor area[Z:(0.64±0.10)vs.(0.70±0.10),P=0.028].Conclusion:The abnormalities of functional connectivity exist in the attentional network of depression during resting-state,which may be associated with cognitive impairment in depression,particularly with attentional decline.更多还原