【摘要】 目的:研究α-干扰素治疗e抗原阳性慢性乙型肝炎(CHB)疗效的影响因素。方法:根据治疗后HBVDNA和ALT水平以及HBeAg是否转阴,将109例采用α-干扰素治疗的e抗原阳性CHB患者,分为应答组和无应答组。用多变量二分类Logistic回归分析研究康氏系列方剂及其他因素对于α-干扰素疗效的影响。结果:选择基线ALT>3倍正常值,HBVDNA<107copies/ml,并且加用康氏系列方剂有助于提高α-干扰素治疗的e抗原阳性CHB的疗效。结论:治疗前患者HBVDNA和ALT水平、是否服用康氏系列中药汤剂为α-干扰素治疗e抗原阳性CHB疗效的影响因素。更多还原

【Abstract】 Objective:To investigate the factors affecting the response to interferon-alpha treatment in patients with HBeAg-positive chronic hepatitis B.Methods:One hundred and nine HBeAg-positive chronic hepatitis B patients were given interferon-alpha treatment.Patients were divided into response group or non-response group based on their HBV DNA level,and whether HBeAg turned negative and ALT returned normal or not.Analysis the Kang’s serial formulas and patients factors affecting the response to interferon-alpha treatment by binary logisitic regression.Results:Interferon-alpha therapy in patients with HBeAg-positive chronic hepatitis B showed better effects on patients with baseline of ALT level>3×ULN,baseline of HBV DNA level <107copies/ml and taking Kang’s serial formulas.Conclusion:The baseline of HBV DNA level,and ALT level,and whether taking Kang’s serial formulas were the influence factors of interferon-alpha treatment in patients with HBeAg-positive chronic hepatitis B.更多还原