【摘要】 目的探讨与原发性高血压(EH)有关的危险因素,为高血压高危人群风险预测提供科学依据和方法。方法采用横断面调查方法,对开滦(集团)有限责任公司1 224例员工进行体格检查和问卷调查。采用聚合酶链反应(PCR)检测ACE基因的Alu I/D多态性;采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)的方法测定血管紧张素原(AGT)基因型和血管紧张素Ⅱ的1型受体(AT1R)基因型;全自动生化仪测定生化指标。结果不同性别、年龄人群的原发性高血压患病率不同(P<0.001);胆固醇、三酰甘油、血尿酸及体重指数异常者,原发性高血压患病率高(P<0.001);打鼾、吸烟、饮酒者、有原发性高血压家族史者患病率高(P<0.001);不同AGT、ACE基因型人群的原发性高血压患病率不同(P<0.001,P=0.027)。不同AT1R基因型人群的原发性高血压患病的差异无显著性(P>0.05)。结论 AGT基因CC基因型、年龄、性别、体重指数、家族史、血尿酸、三酰甘油及打鼾是原发性高血压患病的独立危险因素。更多还原

【Abstract】 【Objective】 To investigate the relationship between risk facts and essential hypertension(EH) so as to provide scientific evidences and approaches for the risk prediction of hypertension.【Methods】 A cross-sectional study was performed in 1224 subjects from Kailuan Coal Mine.The data were obtained by the physical examination and a unified questionnaire.The biochemical parameters were measured by automatic analyzer.The genotype of I/D of ACE was assessed by using polymerase chain reaction(PCR).Polymerize chain reaction-restriction fragment length polymorphism(PCR-RLFP) was used to detect the T704C AGT genotypes and A1166-C of AT1R.【Results】 The result showed that the morbidity of EH was different in different sex and age(P <0.001).The morbidity of EH was higher in people with abnormal cholesterol,uric acid,triglyceride and weight,and in people who had family history of EH,smoking,drinking and snoring(P <0.001).The morbidity of EH varied with different AGT,ACE genotypes(P <0.001,P =0.027).There was no difference in EH morbidity between people with different genotypes of AT1R(P >0.05).【Conclusion】 After a logistic regression analysis,the CC genotype of AGT,age,sex,obesity,snoring,family history,uric acid and glycerinate are independent risk factors of EH.更多还原