【摘要】 目的比较单纯常规治疗及分别联合bFGF、局部氧疗及bFGF/局部氧疗对深Ⅱ度烧伤创面的治疗效果,探讨bFGF联合局部氧疗对烧伤创面愈合的影响。方法 2004年2月-2009年7月,收治85例117个深Ⅱ度烧伤创面,根据治疗方法不同随机分为4组。各组患者性别、年龄、病程、烧伤面积、用药面积等一般资料比较,差异均无统计学意义(P>0.05),具有可比性。常规治疗组(A组)18例28个创面,给予常规治疗。联合局部氧疗组(B组)23例30个创面,在常规治疗基础上每天局部氧疗1次,持续90min。联合bFGF组(C组)19例25个创面,在常规治疗基础上每天给予bFGF(150U/cm2)。联合bFGF/局部氧疗组(D组)25例34个创面,常规治疗同时联合bFGF(150U/cm2)及局部氧疗。bFGF和局部氧疗均以3周为一疗程。结果患者均获随访,随访时间6～12个月,平均9个月。A、B、C、D组创面愈合时间分别为(27.3±6.6)、(24.2±5.8)、(22.2±6.8)、(18.2±4.8)d;D组创面愈合时间与A组比较,差异有统计学意义(P<0.05);其余各组间比较,差异无统计学意义(P>0.05)。A、B、C、D组创面愈合率分别为67.8%±12.1%、85.1%±7.5%、89.2%±8.3%、96.1%±5.6%;A组创面愈合率与B、C、D组比较,差异有统计学意义(P<0.05);其余各组间比较,差异无统计学意义(P>0.05)。A、B、C、D组治疗有效率分别为75%、90%、92%、100%;D组创面治疗有效率与A组比较,差异有统计学意义(P<0.05);其余各组间比较,差异无统计学意义(P>0.05)。治疗后6个月D组温哥华瘢痕量表评分明显优于A组,差异有统计学意义(P<0.05);其余各组间比较,差异无统计学意义(P>0.05)。结论 bFGF联合局部氧疗可以促进深Ⅱ度烧伤创面的愈合,且操作简便。更多还原

【Abstract】 Objective To investigate the efficacy of basic fibroblast growth factor(bFGF) combined with topical oxygen therapy for deep Ⅱ degree burn wounds,by comparing the effects of bFGF combined with topical oxygen therapy and bFGF with routine therapy.Methods From February 2004 to July 2009,85 patients with deep Ⅱ degree burn wounds(117 wounds) were enrolled and divided into 4 groups randomly according to different treatments.There was no significant difference in sex,age,disease course,wound size,and wound treatment size among 4 groups(P > 0.05).In group A,18 patients(28 wounds) were treated routinely;in group B,23 patients(30 wounds) were treated with routine methods and topical oxygen therapy;in group C,19 patients(25 wounds) were treated with routine methods and bFGF therapy;and in group D,25 patients(34 wounds) were treated with routine methods and bFGF/topical oxygen therapy.Topical oxygen therapy was administered to the wound for 90 minutes per day for 3 weeks.The bFGF therapy was applied everyday(150 U/cm2) for 3 weeks.Results All cases were followed up 6-12 months(9 months on average).The wound healing times in groups A,B,C,and D were(27.3 ± 6.6),(24.2 ± 5.8),(22.2 ± 6.8),and(18.2 ± 4.8) days,respectively;showing significant difference between group A and group D(P < 0.05).The wound healing rates in groups A,B,C,and D were 67.8% ± 12.1%,85.1% ± 7.5%,89.2% ± 8.3%,and 96.1% ± 5.6%,respectively;showing significant differences between group A and groups B,C,D(P < 0.05).The therapic effective rates in groups A,B,C,and D were 75%,90%,92%,and 100%,respectively;showing significant difference between group A and group D(P < 0.05).The Vancouver scar scale scoring of group D 6 months after treatment was better than that of group A(P < 0.05).Conclusion The bFGF combined with topicaloxygen therapy can enhance deep Ⅱ degree burn wound healing.Furthermore,the therapy method is simple and convenient.更多还原