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直肠癌术后局部复发和远位转移预后因素分析
Analysis on Factors of Local Recurrence and Distant Metastasis of Rectal Cancer after Operation
【摘要】 目的探讨直肠癌根治术后局部复发和远位转移的影响因素。方法对412例直肠癌患者资料进行复习,其中378例根治术病例加以研究,对于影响直肠癌预后的20个可能相关因素,使用Cox模型进行分析。结果手术切除率91.7%(378/412),手术组中根治切除率为94.7%(358/378)。术后5 a生存率47.6%(180/378)。至2006年底121例术后复发转移,其中局部复发47例,肝转移41例,肺转移9例,骨转移3例;2个以上的同时转移10例,癌肿转移部位不明而死亡者11例。结论直肠癌根治性切除术后局部复发和远位转移的影响因素有6个,依次为分期、原发瘤大小、侵犯深度、淋巴结转移情况、组织分型、大体分型,其余4个因素:病期、肿瘤占据肠腔周径、肿瘤下缘距肛门齿状线的高度和年龄也有一定影响。
【Abstract】 Objective To research the influencing factors in local recurrence and distant metastasis of rectal cancer after operation.Methods To review 412 profiles of rectal cancer patients,study 378 of which using rectal operation,and analyse 20 factors which might influence prognosis of postoperative rectal cancer by COX model.Result The operation excision rate was 91.7%(358/412).The excision rate of radical treatment was 94.7%(358/378).The 5-year survival rate was 47.6%(180/378).By the end of 2006,in total 121 cases had developed recurrence,local recurrence was 47 cases,hepatic metastases were 41 cases,lung metastases 9 cases,bone meetastases 3 cases;10 cases had developed metastases in more than two organs,11 cases died of other causes.Conclusion There are 6 main influencing factors in local recurrence and distant metastasis of rectal cancer after operation: stage,primary tumor size,invasive depth,lymph node metastasis,pathological type,gross type.In addition,circumferential occupation by the tumor,distance between anus and lower margin of the tumor,and age also have some influence on prognosis.
【Key words】 Rectal Neoplasms/surgery; Neoplasm Recurrence,Local; Neoplasm Metastasis;
- 【文献出处】 中国误诊学杂志 ,Chinese Journal of Misdiagnostics , 编辑部邮箱 ,2010年22期
- 【分类号】R735.37
- 【被引频次】1
- 【下载频次】73