【摘要】 目的观察感染性休克患儿T淋巴细胞亚群、NK细胞活性、免疫球蛋白和补体水平,了解感染性休克患儿的免疫功能状态。方法观察20例ICU的感染性休克患儿和20例健康体检小儿的细胞免疫、体液免疫和补体水平。结果①感染性休克患儿CD3、CIM、NK细胞活性和IgM、补体C3水平比健康小儿明显降低[(55.41±21.09)%与(73.93±5.77)%;(20.87±8.16)%与(39.04±4.24)%;(11.56±6.65)%与(16.94±4.55)%;(0.88±0.43)%与(1.32±0.50)%;(0.91±0.36)g/L与(1.31±0.44)g/L;均P<0.01];IgA水平升高[(3.02±1.23)g/L与(2.05±0.71)g/L,P<0.01];结论感染性休克患儿细胞免疫功能和体液免疫功能受到抑制,外周血CD4细胞活性可以反映感染性休克患儿免疫功能。更多还原

【Abstract】 Objective To observe the immunological function in septic shock patients in ICU through observing the T lymphocyte subsets,NK cell,immunoglobulin and complement.Methods The T lymphocyte subsects,NK cell,immunoglobulin and complement in peripheral blood and albumin in serum of 20 septic shock patients in ICU and 20 persons in health examination were observed. Results ①The activity of CD3,CD4,NK cells and IgM,C3 were lower in patients than in healthy controls[(55.41±21.09)%vs(73.93±5.77)%:(20.87±8.16)%vs(39.04±4.24)%;(11.56±6.65)%vs(16.94±4.55)%;(0.88±0.43)%vs(1.32±0.50)%;(0.91±0.36)g/L vs(1.31±0.44)g/L;P<0.01 respectively].Conclusion The cellar and humoral immune function are inhibited and the activity of CD4 could reflect the immune function in septic shock patients.更多还原