【摘要】 目的:通过对嘉兴地区新发现的155例HIV-1抗体阳性的感染者,进行首次的CD4+ T淋巴细胞绝对值等的测定,来了解并估计其的免疫状况及疾病的进展状况。方法:对采集的155份全血样本以四色荧光抗体进行标记,通过流式细胞仪进行CD4+和CD8+ T淋巴细胞绝对值的检测,并计算CD4+/CD8+的比值。统计分析其测定值。结果:嘉兴市能随访到的HIV阳性感染者并完成CD4+ T检测的共计155例,其中CD4+ T淋巴细胞平均为296.68±212.88个/μl,CD4+/CD8+比值平均为0.37±0.24,已有36.8%HIV感染者CD4+ T<200个/μl,CD4+/CD8+<1的占98.1%;不同性别和3种传播途径的CD4+ T淋巴细胞和CD4+/CD8+比值,在结果上无显著性差异;2个年龄组间CD4+ T淋巴细胞有显著性差异,高年龄组的数值要低于低年龄组的。结论:嘉兴市有1/3新发现的HIV感染者已进入艾滋病期,应对其定期检测,估计疾病进展和及时药物治疗;同时要进行更多的艾滋病防治宣传,鼓励更多高危人群进行相关HIV抗体和CD4+ T淋巴细胞的检测,以把握治疗的最佳时期。更多还原

【Abstract】 Objective:To first detect 155 new-found HIV infected persons about the CD4+ T-lymphocyte Count(CD4+ T-LC),in order to better learn their immune status and development of diseases.Methods: 155 samples of whole blood were tested by flow cytometry with 4-color fluorescence labeling antibodies,and analyzed by CD4+ T-LC,CD8+ T-LC and the rate of both(CD4+/CD8+).Results: The mean value of CD4+ T-LC and CD4+/CD8+ rate are 296.68±212.88/μl and 0.37±0.24 respectively,and the persons less than 200/μl(CD4+ T-LC) and 1(CD4+/CD8+ rate) account for 36.8% and 98.1% of tested HIV infected persons.The values between genders and transmission routes are not different obviously,but in two age groups,the values in high age group are lower.Conclusion: In Jiaxing,there are one third of new-found HIV infected persons in AIDS period.It′s necessary for the HIV infected persons and high risk population to be encouraged to accept the relative tests,HIV antibodies and CD4+ T-lymphocytes,so as to grasp the best period of treatment.更多还原