【摘要】 目的:对有妊娠史女性患者进行不规则抗体筛查,以确保临床输血安全,减少溶血性输血反应的发生。方法:选择有妊娠史女性患者1785例、无妊娠史女性患者924例作为对照。采用微柱凝胶法进行不规则抗体筛查与鉴定。结果:有妊娠史组和无妊娠史组的不规则抗体筛查阳性率分别为0.78%和0.11%,两组比较存在显著性差异(χ2=5.04,P<0.05)。有妊娠史组确认特异性抗体13例、非特异性抗体1例;13例特异性抗体为抗D 4例、抗E 6例、抗Ec 1例、抗c 1例、抗M1例。无妊娠史组确认特异性抗体1例为抗E。结论:为确保临床输血的安全有效,对有妊娠史女性患者进行不规则抗体筛查很有必要;同时对有妊娠史的孕妇产前进行不规则抗体筛查,可有效防治新生儿溶血病。更多还原

【Abstract】 Objective:To screen irregular antibody in female patients having pregnancy history,so as to ensure the clinic blood transfusion safety and reduce the occurrence of hemolytic transfusion reaction.Methods:Select 1785 female patients having pregnancy history,924 female patients no pregnancy history as controls.Screen and indentify the irregular antibodies by Mico-Column gel technique.Results:The positive rate of irregular antibodies screening in having pregnancy history group and no pregnancy history group is 0.78% and 0.11%,respectively.There is a significant difference between the two groups(χ2=5.04,P<0.05).Having pregnancy history group confirmed specific antibodies 13 cases and non-specific antibodies 1 case;13 cases of specific antibodies are 4 anti-D,6 anti-E,1 anti-Ec,1 anti-c,1 anti-M.No pregnancy history group confirmed specific antibodies 1 case of anti-E.Conclusion:In order to ensure the safe and effective clinic blood transfusion,screening irregular antibody in female patients having pregnancy history is very necessary;At the same time prenatal screening irregular antibody in pregnant women having pregnancy history can effectively prevent and cure hemolytic disease of the newborn.更多还原