【摘要】 目的本研究检测血管内皮抑素(Endostatin)、碱性成纤维细胞生长因子(bFGF)在人类舌鳞癌组织中的表达及其与临床病理特征的关系。方法收集34例临床和病理完整的舌鳞癌组织采用免疫组化S-P法检测Endostatin、bFGF的表达水平。结果根据舌鳞癌组有无淋巴结转移Endostatin的阳性表达率分别为50.0%,81.8%,bFGF阳性表达率分别为91.7%,59.1%,均有显著差异(P<0.05)。舌鳞癌组织中Endostatin、bFGF表达呈显著负相关(rs=-0.385,P<0.025)。结论 Endostatin和bFGF在舌鳞癌组织肿瘤血管生成过程中是重要的调节因子,二者消长关系可能关系到肿瘤生物学行为的发生发展。更多还原

【Abstract】 Objective To investigate the expression of Endostatin、bFGF in Oral Squamous Cell Carcinoma(OSCC)tissue and their interaction with clinical pathological characteristics.Methods Thirty-four resected specimens of patients undergoing surgery for OSCC were collected.Immunohistochemical staining was used for detecting the expression of Endostatin、bFGF.Results According to the status of lymphnode metastasis the positive rates of Endostatin were 50.0 %,81.8%,the positive rates of bFGF were 91.7%,59.1%.Conclusion Endostatin and bFGF are both important regulators in the process of angiogenesis in OSCC.It suggested that there was a regularly alteration between promoters and inhibitors in OSCC angiogenesis.更多还原