【摘要】 目的研究苏木乙醇提取物(SME)对坐骨神经损伤小鼠神经再生的影响。方法选取成年雄性Balb/c小鼠84只,随机分为SME高中低剂量组和空白对照组,行右侧坐骨神经离断吻合术,分别于术后3、5天1、2、4、8、12周以ELISA法血清髓鞘碱性蛋白浓度,术后4、8、12周行神经电生理检测,将所得结果进行统计学分析。结果各时间点动物的血清髓鞘碱性蛋白浓度及电生理检测结果与SME剂量呈现明确的量效对应关系。结论SME可以通过抑制损伤后的免疫反应,降低神经损伤局部神经的破坏程度,从而加速神经再生。更多还原

【Abstract】 Objective To explore the effect of Caesalpinia sappan ethanol extract on the myelin basic protein in blood serum and the nerve function in mouse after sciatic nerve injury.Methods Adult male Balb/c mouse were randomly divided into the normal control-group and the experimental-group with high middle or low dose of Caesalpinia sappan ethanol extract,the right sciatic nerve was transected and inosculated.The mouse survived for 3,5days and 1,2,4,8,12weeks after operation.The MBP was detected by ELISA and the nerve function was detected by electromyography.Results The concentration of MBP in blood serum and the resules of electromyography had dose-effect relationship with SME.Conclusion Caesalpinia sappan ethanol extract could effect the regeneration of nerve in mouse after sciatic nerve injury,there is dose-effect relationship between SME and the effection.更多还原