【摘要】 磁性纳米粒子具有可以与所感兴趣的生物细胞相结合并增强其磁信号的特点。本研究利用医用脑磁仪中的高灵敏度磁检测系统,对基于纳米磁性粒子的肿瘤早期检测方法进行了探究。论文对4种可与肿瘤细胞结合的不同尺度磁性纳米粒子所产生的磁场进行了检测和仿真分析,并进行了初步的动物实验。结果显示,利用超导量子干涉仪(SQUID)构成的高精度磁检测系统可以对50 nm以上尺度的磁性粒子进行有效检测,该研究为开发基于SQUID和磁性纳米粒子的肿瘤细胞早期检测系统奠定了基础。更多还原

【Abstract】 Magnetic nanoparticles offer possibilities in biomedical applications,such as they can get close to a biological entity of interest and enhance the magnetic signal of interest target.This paper explored the feasibility of a new type of nanoparticle-based cancer imaging method by means of standard clinical magnetoencephalography system equipped with high sensitive magnetic sensors.Four different sizes of nanoparticles which could target the cancer were detected,and the preliminary experiment on animals was carried out.The results showed that magnetic nanopaticles with size of more than 50 nm could be effectively detected by superconducting quantum interference device(SQUID),which laid a foundation for developing the cancer detection system with SQUID and nanoparticles.更多还原