【摘要】 目的了解下呼吸道感染革兰阴性杆菌的常见细菌分布及耐药性情况。以协助临床合理应用抗菌药物。方法对2009年1月至2010年5月住院患者下呼吸道感染痰标本所分离的病原菌,进行菌种和耐药性回顾性统计分析。结果共收集1354株细菌,其中革兰阴性杆菌1095株,占80.87%。革兰阴性杆菌中分离率占前五位的分别是:铜绿假单胞菌250株(占18.46%),鲍曼不动杆菌182株(占13.44%),肺炎克雷伯菌株158株(占11.67%),大肠埃希菌143株(占10.56%),嗜麦芽黄单孢菌86株(占6.35%)。主要革兰阴性杆菌均耐药,对抗菌药物耐药率普遍较高的细菌为鲍曼不动杆菌、肺炎克雷伯菌,大肠埃希菌。结论呼吸道分离的革兰阴性杆菌均存在严重耐药问题,及时监测病原菌变化及耐药趋势以指导临床用药至关重要。更多还原

【Abstract】 Objective To investigate the distribution and drug resistance among Gram-negative bacteria fromrespiratory tract infections and their drug resistance to help reasonably utilize the antibiotics. Methods A retrospective analysis for the antibiotic resistance of pathogen isolated from sputum sample of nosocomial lower respiratory tract infection was mede in OUF hospital from Jan 2009 to Jan 2010. Results A total of 1354 iso-lates of pathogens were collected. Gram-negative bacilli were 1095 ( 80. 87% ) 。the outstanding pathogens were Pseudomonas aeruginosa was 250( 18. 46% ) ,Acinetobacter baumanii was 182 ( 13. 44% ) ,Klebsiella pneu-moniae was 158 ( 11. 67% ) ,Escherichia coli was 143 ( 10. 56% ) ,P seudomonas maltophilia was 86 ( 6. 35%). The dominant Gram-negative pathogenic bacteria were resistan. The resitant rate was higher in Acinetobacter baumanii,Klebsiella pneumoniae,Escherichia coli. Conclusion Drug resistance of isolated pathogenic bacteria from respiratory tract infection is a serious problem. Monitoring the change of pathogen and the trends of antimicrobial resistance is very important in guiding the antibiotic therapy.更多还原