【摘要】 目的探讨60岁以上老年患者肾移植的临床特点,以及影响肾长期存活的因素。方法回顾性分析48例≥60岁老年肾移植患者的临床资料,并以同期<60岁的肾移植患者205例作对照。结果老年组人/肾1、3年存活率分别为89.6%/87.5%、79.1%/75.0%,对照组分别为92.7%/91.7%、81.0%/76.1%,两组比较差异无显著性统计学意义(P>0.05);老年组急性排斥反应发生率为10.4%,与对照组11.1%无显著性统计学差异(P>0.05);老年组术后肺部感染、心血管疾病、肝功能异常等的发生率均高于对照组(P<0.01)。老年组术后住院时间(28.0±11.7)d,显著高于对照组的(19.8±8.7)d(P<0.05)。结论老年患者进行肾移植时,心血管并发症和感染是引起死亡的主要原因。术前应慎重选择、充分准备、严格配型,术后合理使用免疫抑制剂、积极预防和及时处理并发症。更多还原

【Abstract】 Objective To investigate the features of kidney transplantation in patients over 60 years old and along with infection renal perennial survive complication.Methods Retrospective analysis was held on 48 elderly patients aged over 60 years who underwent renal transplantation,and compared with 205 patients under the ags of 60 years who underwent the renal transplantation during the same time.Results The patient/graft survival rates of senile group at 1,3 years were 89.6%/87.5%、79.1%/75.0%,respectively with no significant difference from the control group(P>0.05).The rate of acute rejection response was 10.4% in elderly patients,significantly lower than in non-elderly patients(11.1%).The postoperative incidence of pulmonary infection was higher(P<0.01)and so were the hepatic dysfunction,heart failure.Conclusion Satisfactory effects could be obtained in senile patients after renal transplantation if cautious selection,rational preparation and strict match were conducted before operation and reasonable use of immunosuppressive agents,actively preventing and treating complications were performed after operation.更多还原