【摘要】 目的描述和评价广西壮族自治区接受一线高效抗反转录病毒治疗方案的儿童艾滋病患者的临床特点及疗效。方法以68例以往未接受过抗反转录病毒治疗的儿童艾滋病患者作为研究对象进行队列分析,对治疗基线以及治疗后每3～6个月患儿的CD4+T淋巴细胞百分比以及病毒载量进行统计分析,以评估该组儿童艾滋病患者抗病毒治疗效果。结果患儿平均年龄为3岁(0.2～8岁),其中男39例,女29例,感染途径皆为母婴传播。高效抗反转录病毒治疗方案:行AZT+3TC+NVP者52例,D4T+3TC+NVP者16例。患儿接受抗反转录病毒治疗后,CD4+T淋巴细胞百分比显著升高,治疗满12个月、24个月、36个月的患儿CD4+T淋巴细胞百分比分别为23.8%、28.0%、30.0%。治疗1年以上,病毒载量控制在400拷贝/ml以下的患儿比例为62%～83%。结论在资源有限地区,规范使用一线AZT/D4T+3TC+NVP方案,可以明显改善儿童艾滋病患者免疫学和病毒学状况。更多还原

【Abstract】 Objective To describe and evaluate the clinical characteristics and efficacy of pediatric AIDS patients on first-line highly active antiretroviral therapy in Guangxi Zhuang Automous Region.Methods Total of 68 antiretroviral-naive,AIDS children were enrolled in this study.CD4+ T lymphocytes percentage and HIV-1 RNA viral load were measured before HAART and effect of HARRT in this region was assessed every 3-6 months during treatment.Results The median age was 3 (0.2-8) years old,39 (57.4%) were male and 29 (42.6%) were female.All of them were infected with HIV via mother-to-child-transmission.Fifty two patients (76.5%) began with AZT + 3TC +NVP regimen as well as 16 (23.5%) with D4T+ 3TC+NVP regimen.CD4+ T lymphocytes percentage increased to 23.8%,28.0% and 30.0% after 12 months,24 months and 36 months treatment,respectively.After 12 months,the percentage of children’s viral load less than 400 copies/ml ranged from 62% to 83%.Conclusions This study suggests that first-line HARRT with AZT or D4T + 3TC +NVP regimen may induce benefical virological and immunological outcomes from AIDS children in resource limited areas.更多还原