【摘要】 目的探讨肝硬化门静脉高压症(LCPH)患者并发肝肺综合征(HPS)时血浆一氧化氮(NO)和内皮素1(ET-1)水平的变化及其意义。方法回顾分析52例LCPH患者临床资料。按有无并发HPS分为Ⅰ(并发HPS)组和Ⅱ(未并发HPS)组。应用硝酸还原酶法检测血浆NO水平,放免法检测血浆ET-1水平。结果HPS总发生率为11.5%(6/52),Child-Pugh C级发生率为30%(3/10)。Ⅰ组Child-Pugh C级的比例为50%(3/6),血浆NO水平达(110.40±28.02)μmol/L,明显高于Ⅱ组(P<0.01),而血浆ET-1水平两组间差异无统计学意义(P>0.05)。结论血浆NO水平升高是HPS发生的重要特征;提示联合肝功能Child-Pugh分级,对LCPH并发HPS有诊断意义。更多还原

【Abstract】 Objective To study the relationship between plasmic nitric oxide(NO),endothelin-1(ET-1) levels and occurrence of hepatopulmonary syndrome(HPS) in liver cirrhosis with portal hypertension(LCPH) patients.Methods Fifty-two LCPH patients were divided into group Ⅰ(with HPS) and groupⅡ(without HPS).Plasmic NO and ET-1 levels were detected by nitric acid reductase and radioimmunoassay(RIA) respectively.Results Occurrence of HPS in all patients was 11.5%(6/52),and was 30%(3/10) in Child-Pugh class C patients.In group Ⅰ,50%(3/6) patients were in Child-Pugh class C.The comparison showed that plasmic NO levels were significantly higher in group Ⅰ than that in group Ⅱ[(110.40±28.02)μmol/L vs.(79.56±22.12)μmol/L,P<0.01],but there was no significant difference in ET-1 levels(P>0.05).Conclusions Elevated plasmic NO levels is an important characteristic of HPS,and,when combined with Child-Pugh classification,it can be significant for diagnosis of HPS in LCPH patients.更多还原