【摘要】 目的研究胃癌新辅助化疗疗效临床评价方法及进展。方法对有关胃癌新辅助化疗疗效临床评价方法的文献进行综述分析,比较CT、EUS、MRI及PET的评价结果与术后病理、预后结果的符合度。结果CT、EUS是目前临床中常用的疗效评价方法,但是其评价指标和标准不统一,胃癌套用现有的实体瘤疗效评价标准似乎并不适用;采用磁共振扩散加权成像(DWI)评价胃癌新辅助化疗疗效还有待进一步研究;PET在早期准确筛选出化疗无效病例方面具有优势。结论胃癌新辅助化疗疗效临床评价尚缺乏统一标准,各种影像学方法的综合应用可能有利于提高评价的准确性。更多还原

【Abstract】 Objective To investigate the advances and clinical efficacy evaluation method on neoadjuvant chemotherapy in patients with gastric cancer. Methods Literatures on the advances and clinical efficacy evaluation method on neoadjuvant chemotherapy in patients with gastric cancer were reviewed and analyzed. The agreement between computed tomography (CT),endoscopic ultrasound (EUS),magnetic resonance imaging (MRI) and positron emission tomography (PET) and the results of histopathology and survival was analyzed. Results CT and EUS were the method of efficacy evaluation commonly used at present,but the evaluation indexes and criteria were controversial,and the criteria for solid tumors seemed to be not feasible for gastric cancer. Diffusion-weighted imaging (DWI) method needed more investigation,while PET held advantage in early selection of patients without response accurately. Conclusion There is no uniform standard for clinical efficacy evaluation yet,so an integration of diverse imaging methods may be the best choice to improve the accuracy of neoadjuvant chemotherapy in patients with gastric cancer.更多还原