【摘要】 目的:探讨艾司西酞普兰对抑郁症的疗效及安全性。方法:84例抑郁发作患者随机分为艾司西酞普兰组和帕罗西汀组,分别给予艾司西酞普兰和帕罗西汀治疗,疗程8周,以汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)评定疗效,以治疗中出现的症状量表(TESS)评定不良反应。结果:治疗1~2周,艾司西酞普兰组HAMD、HAMA评分均较帕罗西汀组显著下降(P均<0.05);治疗4~8周,艾司西酞普兰组有效率和治愈率分别为74.1%和59.2%,帕罗西汀组有效率和治愈率分别为79.6%和63.1%,两组差异无显著性(P>0.05)。艾司西酞普兰组不良反应总发生率21.6%,较帕罗西汀组44.4%显著为低(P<0.05)。结论:艾司西酞普兰治疗抑郁症疗效与帕罗西汀相似,安全有效,不良反应较轻。更多还原

【Abstract】 Objective:To compare efficacy and side effects between escitalopram and paroxetine in the treatment of depression.Methods:84 inpatients and outpatients with a diagnosis of depression according to CCMD-3 were involved in this study,they were randomly assigned to escitalopram group(n = 42) and paroxetine group(n = 42) for 8weeks.Effects and side reactions were evaluated with HAMD,HAMA,CGI-SI and TESS before and after the treatment.Results: Findings indicated that efficacy of escitalopram was similar to than of paroxetine,however escitalopram took effect more quickly and its side effects were less than paroxetine.Conclusions: Escitalopram is an effective and safe antidepressant.It is suggested that escitalopram could be used as a first-line antidepressant in the treatment of depression.更多还原