【摘要】 目的:评价利培酮和奋乃静治疗女性精神分裂症的疗效和不良反应。方法:对68例女性精神分裂症患者随机分为两组,分别给予利培酮与奋乃静治疗,疗程8周。用阳性与阴性症状量表(PANSS)与不良反应量表(TESS)评定疗效和不良反应。结果:两组总的疗效差异无显著性(P>0.05),但利培酮起效较快;且在治疗阴性症状方面,以利培酮显著较好(P<0.05)。利培酮组不良反应较奋乃静组少,其中静坐不能、心动过速、震颤、视物模糊显著少于奋乃静组(P<0.05)。结论:利培酮是一种安全有效的抗精神病药。更多还原

【Abstract】 Objective:To detect the clinical efficacy and side effects of Risperidone and Perphenazine in the treatment of female schizophrenic patients. Methods:68 female schizophrenic patients have been divided into Risperidone group and Perphenazine group randomly to treat for 8 weeks. Positive and negative syndrome scale (PANSS) and treatment emergent symptom scale (TESS) were used to evaluate the efficacy and side effects respectively.Results:There were no significant difference between two groups (P>0.05).However,Risperidone took effect more quickly But,significant difference were found between two groups in the reduction rate of scale about negative symptoms (P<0.05).Patients in Risperidone group reported much fewer side effects than those in Perphenazine group,especially in the items of skathisia,tachycardua,tremor,and blur sight on TESS (P<0.05).Conclusions:Risperidone is an effective antipsyshotic drug with fewer side effects.更多还原