【摘要】 目的比较帕米磷酸二钠与唑来膦酸治疗恶性肿瘤骨转移性疼痛近期疗效及不良反应.方法将150例恶性肿瘤骨转移患者随机分为两组,帕米磷酸二钠组70例,唑来磷酸组80例.给药方法 :帕米磷酸二钠注射液60 mg,加入500 mL生理盐水内,静脉滴注4 h;唑来膦酸注射液4 mg,加入100 mL生理盐水内,静脉滴注20 min.两组均每4周给药1次,共3次.结果帕米磷酸二钠、唑来膦酸组临床受益率分别为84.3%,87.5%;生活质量改善率分别为45.7%,48.8%.两者疗效及不良反应差异无统计学意义(P>0.05).结论两组药物疗效及不良反应相似,但唑来膦酸使用更为方便,帕米磷酸二钠价格则较为低廉.更多还原

【Abstract】 Objective To compare the short-term efficacy and side effects of Zoledronic acid and those of Pamidronate disodium in the treatment of pain induced by skeletal metastases of malignant tumor.Method150 patients with the malignant tumor bone matastases were divided randomly into the Pamidronate disodium group(70 cases) and Zoledronic acid group(80 cases).Administration method:60 mg Pamidronate disodium added into 500 mL normal saline was administered in intravenous infusion for 4 hours and 4 mg Zoledronic acid added in 100 mL normal saline within 20 minutes,and both one time every 4 weeks for 12 weeks.ResultsThe clinical benefit response rate of Pamidronate disodium and Zoledronic acid groups was 84.3% and 87.5% separately,the improvement rate of life quality was 45.7% and 48.8% respectively.The adverse reaction is little difference(P>0.05) in the therapeutic effect and adverse reactions between them.ConclusionThere is no difference in clinical efficacy and side effects between the two drugs,but Zoledronic acid is more convenient to be administered than Pamidronate disodium,while Pamidronate disodium is cheaper than Zoledronic acid.更多还原