【摘要】 目的探讨术后脑胶质瘤调强适形放疗的临床疗效。方法30例脑胶质瘤予术后调强适形放疗,以90%～95%等剂量线包绕计划靶体积(PTV)。肿瘤靶体积(GTV)照射(58～70)Gy/(28～33)f,临床靶体积(CTV)照射(56～66)Gy/(28～33)f,PTV照射(50.4～60)Gy/(28～33)f,1次/天,5f/w。结果完全缓解率(CR)23.3%(7/30),部分缓解率(PR)66.7%(20/30),稳定率为10%(3/30)。1、2、3年总生存率分别为93.3%、76.7%、60%。Ⅰ～Ⅱ级1、2、3年生存率分别为100%、94.1%、76.5%;Ⅲ～Ⅳ级1、2、3年生存率分别为84.6%、53.8%、38.5%。Ⅰ～Ⅱ级组与Ⅲ～Ⅳ级组相比差异有统计学意义(P=0.0153)。患者对治疗的耐受性良好,不良反应主要为颅高压症状,放射性脑水肿。结论脑胶质瘤术后调强适形放疗疗效好,无严重不良反应。更多还原

【Abstract】 Objective To analyze the outcome of intensity modulated radiation therapy(IMRT).Methods Thirty patients with malignant gliomas were received postoperative intensity modulated radiation therapy,the 90%~95% isodose curve include planning target volume(PTV).The prescription dose was (58~70) Gy/(28~33) f to GTV(gross target volume),(56~66) Gy/(28~33) f to CTV (clinical target volume),(50.4~60) Gy/(28~33) f to PTV,1 f/d,5 f/w.Results The complete response (CR) rate was 23.3%(7/30),the partial response (PR) was 66.7%(20/30),stable disease(SD) was 10%(3/30).The 1-year,2-year and 3-year survival rates were 93.3%,76.7%,60% respectively.The 1-year,2-year and 3-year survival rates were 100%,94.1%,76.5% for grade Ⅰ~Ⅱ,and 84.6%,53.8%,38.5% for grade Ⅲ~Ⅳ respectively.There was significant difference (P=0.0153).All patients showed well toleration in this treatment scheme.The main side effects were intracranial hypertension,cerebral edema.Conclusion IMRT is an effective and safe treatment in the patients with malignant gliomas.更多还原