【摘要】 红霉素产生菌基因工程改造发展迅速,不仅合成了100多种红霉素结构类似物,而且在提高红霉素产量方面也取得了重要进展。随红霉素产生菌S.erythraea基因组序列的公布,使基因工程改造红霉素产生菌成为研究的热点。本文综述了采用基因工程手段对红霉素途径中的代谢节点、后修饰酶和聚酮合成酶基因改造的进展。更多还原

【Abstract】 Gene modifi cation of erythromycin-producing strain S.erytheara made a rapid progress,including biosynthesizing more than 100 analogues of erythromycin and improving the erythromycin production.With the release of gene sequences of S.erytheara,it is becoming the hot topic to modify the gene of S.erytheara.This paper summarized the modifi cation of metabolite nodes,genes of modifi ed enzymes and polyketonase.更多还原