【摘要】 目的:TRPP亚家族是TRP(transient receptor potential)超家族中的一个重要成员。它有6个疏水跨膜结构,并且在第一和第二跨膜区间有一个大的胞外环,氨基端有2~4个锚蛋白重复区,羧基端则有较大的变异。TRPP包含有TRPP2、TRPP3、TRPP5等。它们在基本结构、激活方式及功能上均不完全相同。TRPP亚家族与多种生理学机制有关,它的结构异常也可以导致多囊肾的形成。该家族通道蛋白还与人类味觉系统密切相关。文中综述了近年来关于TRPP亚家族的最新研究成果,以及在多囊肾疾病中的相关研究,希望对此通道和相关功能有更深入地了解,为未来突破该疾病的治疗提供更多的思路。更多还原

【Abstract】 TRPP subfamily is an important member of transient receptor potential family.It has six transmembrane(TM) domains,a large extracellular loop between the first and second TM and 2-4 ankyrin repeats in the N terminal.TRPP subfamily includes TRPP2,TRPP3,TRPP5 etc.There are several differences in their structure,activation mode and function.TRPP subfamily is involved in many physiological mechanisms and its abnormal structure can lead to the formation of polycystic kidney.This subfamily is also closely related to gustation.In this review,we summarize recent research findings of TRPP subfamily and its association with polycystic kidney diseases.更多还原