【摘要】 目的:通过对白血病肝脏浸润(LIL)病例与正常对照组的肝脏二维化学位移磁共振31磷波谱成像(2D CSI31P MRS)对照研究,探讨LIL的肝脏磷化合物代谢特征变化。方法:收集LIL15例,并与12例正常肝脏作对照,进行2D CSI31P MRS肝脏扫描,检测各种磷代谢物包括磷酸单酯(PME)、磷酸双酯(PDE)、三磷酸腺苷(ATP)、无机磷(Pi)的相对值,经体模所测校正系数校正后,分析PME、PDE、Pi、ATP的校正相对值(以下简称相对值),及PME/PDE、PME/ATP、PDE/ATP、Pi/ATP、PME/(PME+PDE)的比值变化。结果:在所测的肝脏磷代谢物相对值中,仅LIL组的PME相对值升高,为1.992±0.876,与对照组(1.167±0.427)相比有显著性差异,P<0.05;其它各磷代谢物相对值均无差异。比较LIL与正常对照组之间磷代谢物比值,发现LIL组中与PME相关的比值包括PME/PDE、PME/ATP和PME/(PME+PDE)比值升高,分别为0.551±0.339、1.402±0.654和0.326±0.13,与对照组(分别为0.254±0.059、0.792±0.232和0.199±0.049)相比有显著性差异,P<0.01;LIL组的其它磷代谢物比值与对照组相比均无显著差异。结论:肝31P MRS检查为LIL提供新的非创伤性检测和评价方法,肝脏PME相对值及其相应比值升高提示白血病患者肝浸润存在的可能。更多还原

【Abstract】 Objective: To evaluate the changes of phosphorus metabolites in leukemic infiltration of liver(LIL) with two-dimensional chemical shift imaging(2D CSI) 31phosphorus MR spectroscopy(31P MRS).Methods: Fifteen patients with LIL and 12 healthy subjects(control group) were scanned with liver 2D CSI 31P MRS by a 1.5T MR Scanner(Sonata,Siemens Corporation).Relative quantification of phosphorus metabolites including phosphomonoesters(PME),inorganic phosphate(Pi),phosphodiesters(PDE) and β-adenosine-triphosphate(β-ATP) were detected and after calibrated with model factor,the ratios of PME/PDE,PME/(PME+PDE),PME/ATP,PDE/ATP and Pi/ATP were analyzed.Results: Compared with control group,the PME value,PME/PDE ratio,PME/(PME+PDE) ratio and PME/ATP ratio were increased in LIL group(1.992±0.876 vs 1.167±0.427,P<0.05),(0.551±0.339 vs 0.254±0.059,P<0.01),(0.326±0.13 vs 0.199±0.049,P<0.01)and(1.402±0.654 vs 0.792±0.232,P<0.01) respectively.Conclusion: 31P MRS examination can be used as a non-invasive procedure to evaluate the changes of phosphorus metabolites of leukemic infiltration of liver.The increase of PME value and its ratios to PDE,ATP and PME+PDE may indicate leukemic infiltration of liver.更多还原