【摘要】 [目的]探讨中成药制剂鹿茸多肽-壳聚糖-蜂蜜混悬剂对褥疮愈合的影响。[方法]采用猪压疮为褥疮模型。以蜂蜜为溶剂性载体,将鹿茸多肽和壳聚糖以不同比例混悬于蜂蜜中,制成混悬剂,敷于创面,每天1次,连续7 d,以后隔日换药一次。观察创面愈合情况,计算创面面积。观察创面病理组织学改变。[结果]鹿茸多肽-壳聚糖-蜂蜜混悬剂中鹿茸多肽与壳聚糖4∶1组创面渗出少,肉芽组织生长快,结痂脱落早而完全。病理结果显示鹿茸多肽与壳聚糖4∶1组无坏死组织,上皮化明显,炎症细胞少,无水肿,新生血管数多。[结论]鹿茸多肽-壳聚糖-蜂蜜混悬剂在褥疮的修复过程中起到明显的促进作用,其可能的机制有待于进一步研究。更多还原

【Abstract】 [Objective]To study the influence of VAP(velvet antler polypeptide)-chitosan-honey suspension on decubitus ulcer.[Method]Swines’pressure ulcers were used as decubitus ulcer model.Honey was used as solvent carrier.VAP and chitosan were put into the honey in different proportion.The suspension was applied to the ulcer once a day for seven days.The dressings were changed once every other day.The healing state of the ulcer was observed and the area of the ulcer was calculated.The changes of the ulcer histopathology were observed.[Result]In the group of the suspension proportion of the VAP to the chitosan was 4:1,the wounds had little effusion and the granulation tissues grew fast with the scars falling off early and Absolutely.Pathology results indicated that in the group of the suspension proportion of the VAP to chitosan was 4:1,none necrosis was found,the epithelization was apparent,and the inflammatory cells were fewer.There was no edema,but more newly born blood vessles.[Conclusion]The VAP-chitosan-honey suspension could apparently promote the healing of decubitus ulcer,but the possible mechanism needs to be further studied.更多还原