【摘要】 目的探讨脑囊虫病的治疗效果和免疫学检查的价值。方法将60例脑囊虫病患者随机分为两组,分别给予吡喹酮与丙硫咪唑治疗,并在治疗前后进行免疫学检查。结果吡喹酮治疗组和丙硫咪唑治疗组总有效率分别为83.33%和80.0%,差异无统计学意义(P>0.05);不良反应发生率吡喹酮组为70.00%,丙硫咪唑组为23.33%,差异有统计学意义(P<0.01)。60例脑囊虫病患者治疗前后血清、脑脊液IHA阳性率分别为88.33%和85.00%、58.33%和53.33%,ELISA阳性率分别为93.33%和88.33%、63.33%和58.33%,差异均无统计学意义(P>0.05);IgG4阳性率分别为76.67%和18.33%、51.67%和13.33%,差异有统计学意义(P<0.01)。结论吡喹酮和丙硫咪唑治疗脑囊虫病疗效相当,但丙硫咪唑的不良反应发生率低。脑脊液囊虫免疫学检查阳性率较血清低,血清特异IgG4检查对脑囊虫病的诊断和疗效评价具有一定的参考价值。更多还原

【Abstract】 Objective To investigate the therapeutic efficacy and diagnostic value of the immunodiagnosis of cerebral cysticercosis.Methods Sixty patients with cerebral cysticercosis were randomly divided into two groups: group 1 was given praziquantel and group 2 was given albendazole.Clinical manifestations and immunology results were analyzed for all 60 patients.Results Total efficacy was 83.3% for the praziquantel treatment group and 80.0% for the albendazole treatment group;the difference was not significant(P>0.05).The praziquantel group had a higher incidence of adverse effects(70.00%) than the albendazole group(23.33%);the difference was statistically significant(P<0.01).Before and after treatment,serum and cerebrospinal fluid were positive for IHA at rates of 88.33% and 85.00% and 58.33% and 53.33%.ELISA results were positive at rates of 93.33% and 88.33% and 63.33% and 58.33%;the difference was not significant(P>0.05).IgG4 was positive at rates of 76.67% and 18.33% and 51.67% and 13.33%;the difference was statistically significant(P<0.01).Conclusion Praziquantel and albendazole had equivalent therapeutic efficacy at treating cerebral cysticercosis.Albendazole had a lower incidence of adverse effects.Immunology results for cerebrospinal fluid tended to be positive at a lower rate than immunology results for blood in patients with cerebral cysticercosis.Serum-specific IgG4 has value as a method of diagnosing cerebral cysticercosis and assessing therapeutic efficacy of its treatment.更多还原