【摘要】 目的了解温州地区社区与医院获得性尿路感染病原学组成特点及对抗菌药物耐药状况,为尿路感染经验用药提供指导。方法随机抽取4所不同级别医院门诊患者社区性尿路感染与住院患者医院获得性尿路感染尿培养阳性标本,对社区获得性尿路感染(试验A组)及医院获得性尿路感染(试验B组)各300株病原菌进行归类、对照,对其耐药性进行比较分析。结果社区获得性尿路感染的病原菌排列依次为大肠埃希菌(46.7%)、粪肠球菌(14.3%)、表皮葡萄球菌(7.7%)等;医院获得性尿路感染的病原菌排列依次为大肠埃希菌(26.3%)、白色假丝酵母菌(14.3%)、粪肠球菌(10.7%)等;社区获得性尿路感染的病原菌耐药性高于其他地区;两组大肠埃希菌分离株对亚胺培南及美罗培南的耐药率分别为0.7%、1.27%及2.14%、1.27%。结论温州地区医院获得性尿路感染真菌感染比例高;多药耐药菌株检出率高;规范抗菌药物使用与耐药菌管理迫在眉睫。更多还原

【Abstract】 OBJECTIVE To make acquaintance with etiological composition features and drug resistance of urethrae infection acquired from communities and hospitals in Wenzhou,and to provide instructions of drug administration for urethral infection in this area.METHODS The positive samples of urine culture of urethral infection acquired from four different care level hospitals with inpatient department and community clinics were randomly draw out.The positive strain numbers of urethral infection from the communities and hospitals were the same.Totally 300 strains of pathogens sampled from community group were defined as Group A,300 strains from the hospital as Group B.The pathogens of Group A and Group B were classified and compared respectively,and the drug resistance was analyzed.RESULTS The main pathogens of community-acghired urethral infection was Escherichia coli(46.7%),Enterococcus faecalis(14.3%),Staphylococcus epidermidis(7.7%),etc.The order of pathogenic bacteria of hospital-acquired urethral infection was E.coli(26.3%),Candida albicans(14.3%),E.faecalis(10.7%),etc.The pathogenic bacteria of urethra infection in communities were higher than that of other areas.The isolated strains of the E.coli in two groups presented individual drug resistance against imipenem and meropenem with the drug resistant rates of 0.7%,1.27% and 2.14%,1.27%,respectively.CONCLUSION High fungal infection rate of urethral infection presents in local hospitals of Wenzhou;the detectable rate of multi-drug resistant strains is high.Standardizion the application of antibiotics and the management of drug resistant bacteria are urgent.更多还原