【摘要】 目的了解葡萄球菌属感染的分布及耐药情况,为指导临床合理使用抗菌药物提供依据。方法从临床患者标本中分离162株葡萄球菌属进行鉴定,并进行耐甲氧西林金黄色葡萄球菌(MRSA)及耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)检测,并结合临床相关资料进行分析。结果 162株葡萄球菌属中金黄色葡萄球菌74株(45.68%),溶血葡萄球菌28株(17.28%),表皮葡萄球菌24株(14.8%);检出MRSA52株(70.27%),MRCNS72株(81.82%),MRSA和MRCNS对青霉素耐药率均为100.00%,对替考拉宁的耐药性为11.54%和11.11%,未发现耐万古霉素菌株。结论替考拉宁和万古霉素对葡萄球菌属仍然保持很高的抗菌活性,但葡萄球菌属对替考拉林的耐药情况,应引起临床高度重视,应依据药物敏感性合理使用抗菌药物。更多还原

【Abstract】 OBJECTIVE To study the distribution and drug resistance status of Staphylococcus so as to offer evidence for the rational use of antibiotics in the clinic.METHODS Careful identification and meticillin-resistant Staphylococcus(MRSA),meticillin-resistant coagulase-negative Staphylococcus(MRCNS)tests were made to all 162 strains of staphylococci isolated from clinical specimens,and then the results and related clinical data were analyzed.RESULTS Of all the 162 Staphylococcusstrains,74(45.68%) were S.aureus,28(17.28%) were S.haemolyticus;24(14.8%) were S.epidermidis.Among the samples 52(70.27%)were meticillin-resistant S.aureus(MRSA) and 72(81.82%) were MRCNS by test.The drug resistance rate of MRSA and MRCNS to penicillin was 100%,and to teicoplanin was 11.54% and 11.11%,respectively.No vancomycin-resistant MRSA and MRCNS were detected.CONCLUSION At present teicoplanin and vancomycin remain to possess high antimicrobial activity on Gram-positive cocci,while the drug resistance of staphylocci to teicoplanin should be paid more attention in the clinic,microbial sensitivity should be taken into consideration for the rational use of antibiotics.更多还原