【摘要】 目的观察血必净对大面积烧伤患者血清肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)以及血小板计数(PLT)、凝血酶原时间(PT)、凝血酶时间(TT)、纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)的影响。方法近4年总面积>30%的烧伤患者24例,随机分为常规治疗组和血必净组,每组12例;常规治疗组根据体重、烧伤面积、烧伤深度行补液复苏,抗感染以及保护各脏器功能等对症支持治疗;血必净组在常规治疗组的基础上加用血必净注射液50mL配伍生理盐水100mL静脉滴注,2次/d。检测两组患者治疗第1、2、5和7天血清中TNF-α、IL-6浓度变化;第7天PLT、PT、TT、FIB、APTT的变化。结果 (1)治疗第1、2和5天,常规治疗组和血必净组TNF-α和IL-6均明显高于正常值(P<0.05);治疗第5天和第7天,血必净组TNF-α和IL-6水平明显低于常规治疗组(P<0.05);治疗第7天,常规治疗组TNF-α和IL-6水平显著高于正常值(P<0.05),而血必净组和正常值比较差异无统计学意义(P>0.05)。(2)常规治疗组PLT和FIB明显低于正常值和血必净组,而血必净组与正常值之间差异无统计学意义(P>0.05)。常规治疗组APTT、PT和TT明显延长,与正常值相比有统计学意义(P<0.05),血必净组APTT、PT和TT较常规治疗组显著缩短(P<0.05),与正常值相比无统计学意义(P>0.05)。结论血必净注射液可有效的抑制大面积烧伤患者血清中TNF-α和IL-6的释放,减轻APTT、PT和TT的异常。更多还原

【Abstract】 Objective To study the effect of Xuebijing injection on TNF-α,IL-6 and PLT, PT, TT, FIB, APTT of burn patients. Methods Twenty-four burn patients were randomly divided into 2 groups: control group and Xuebijing group. In control group, patients were treated with routing fluid resuscitation, antibiotics etc. In Xuebijing group, patients were treated with methods of control group and intravenous Xuebijing injection (50 ml added into NS 100 ml, twice a days). Concention of TNF-α and IL-6 in blood serum, PLT, PT, TT, FIB, and APTT were both measured in all patients on admission to hospital and on the 2nd, 5th, 7th day respectively. Results Concentrations of serum TNF-α and IL-6, at day 1, day 2 and day 5, were markedly higher in the control group and the Xuebijing group than that in the normal value measured on admission (P<0.05). At the 7th day, serum TNF-α and IL-6 levels in the control group were higher than normal value. However, serum TNF-α and IL-6 levels in the Xuebijing group were statistically lower than that in the control group at 5th day and 7th day (P<0.05). Moreover, there was no significant difference in concentrations of serum TNF-α and IL-6 between the Xuebijing group and the normal group at the 7th day (P>0.05). PLT and FIB in the control group were lower than those in the Xuebijing group and the normal group, while APTT, PT and TT were significantly longer in Xuebijing group compared to that in the control group (P<0.05). Furthermore, there was no significant difference between the Xuebijing group and the control group at the 7th day (P>0.05). Conclusion Xuebijing injection has influence on coagulation function through decreasing serum TNF-α and IL-6 of burn patients.更多还原