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芍药苷和芍药内酯苷的微生物转化
Microbiological transformation of paeoniflorin and albiflorin
【摘要】 目的:研究芍药苷和芍药内酯苷的微生物转化。方法:从18种真菌中筛选出分别对芍药苷和芍药内酯苷转化能力强的菌株进行转化,采用色谱和波谱技术分离鉴定转化产物。结果:对芍药苷和芍药内酯苷转化能力较强的菌株分别是短刺小克银汉霉AS 3.970和总状共头霉AS 3.264。短刺小克银汉霉AS 3.970可将芍药苷转化为芍药内酯苷,总状共头霉AS 3.264可将芍药内酯苷转化为芍药苷。结论:特定条件下,芍药苷和芍药内酯苷可以相互转化。
【Abstract】 Objective: To investigate the microbiological transformation of paeoniflorin and albiflorin.Method: The bacteria strains able to transform paeoniflorin and albiflorin were screened from 18 strains of microorganisms.The products were isolated by chromatography method and their structures were elucidated by spectral technology.Result: It was found that Cunninghamella blakesleana(AS 3.970) and Syncephalastrum racemosum(AS 3.264) could convert paeoniflorin and albiflorin efficiently,respectively.C.blakesleana could convert paeoniflorin to produce albiflorin,while S.racemosum could convert albiflorin to produce paeoniflorin.Conclusion: Paeoniflorin and albiflorin could be converted each other in definited condition.
【Key words】 paeoniflorin; albiflorin; microbiological transformation; Cunninghamella blakesleana AS 3.970; Syncephalastrum racemosum AS 3.264;
- 【文献出处】 中国中药杂志 ,China Journal of Chinese Materia Medica , 编辑部邮箱 ,2010年07期
- 【分类号】R284.1
- 【被引频次】11
- 【下载频次】714