【摘要】 方法:运用硅胶柱色谱、Sephadex LH-20柱色谱等分离技术,对中国南海软珊瑚Sinularia sp.的醋酸乙酯部分进行了化学成分的研究。利用1D和2D NMR,EI-MS等分析方法对化合物进行了结构鉴定。结果:从中分离得到6个西松烷二萜类化学成分,分别鉴定为lobophytolide A(1),3-dehydroxylpresinularolide B(2),sarcophine(3),3β-acetoxyisolobophytolide(4),crassocolide D(5),(3E,7E,11E)-6-acetoxy-3,7,11,15(17)-cembratrien-16,14-olide(6)。对分离得到的化合物进行了肿瘤细胞抑制活性的初步筛选。结论:化合物1～6均为首次从该生物中获得。更多还原

【Abstract】 A soft coral Sinularia sp.,collected from the South China Sea,was selected to investigate the bioactive and chemical constituents.The EtOAc fraction were isolated by repeatedly silica gel and Sephadex LH-20 column chromatography to obtain lobophytolide A(1),3-dehydroxylpresinularolide B(2),sarcophine(3),3β-acetoxyisolobophytolide(4),Crassocolide D(5),(3E,7E,11E)-6-acetoxy-3,7,11,15(17)-cembratrien-16,14-olide(6).The structures of compounds 1-6 were determined on the basis of spectroscopic data analysis.All compounds were tested against a small panel of human tumor cell lines.And these compounds were obtained for the first time from this coral.更多还原