【摘要】 目的观察辛伐他汀对老年去卵巢大鼠骨量丢失的治疗作用。方法10月龄SD大鼠行双侧卵巢切除术,术后2个月开始用药物治疗,用药2个月后用骨组织形态计量学方法测定大鼠第四腰椎松质骨静态、动态参数,大鼠第五腰椎体应用骨生物力学方法作椎体压缩试验。结果辛伐他汀使去卵巢大鼠骨小梁面积(%Tb.Ar)增加不明显,与去卵巢组相比,差异无统计学意义;但辛伐他汀可改善去卵巢大鼠椎骨的生物力学状况,表现在能使去卵巢大鼠的破坏载荷和破坏应力增加。结论辛伐他汀对老年去卵巢大鼠椎骨的生物力学状况有改善作用。更多还原

【Abstract】 Objective The present study was designed to investigate the preventive effects of simvastatin on osteopenia in aged ovariectomized(OVX)rats.Methods Female,10-month-old SD rats were ovariectomized(OVX)and,2 months later,were treated with simvastatin or controls for 2 months.The static and dynamic parameters in trabecular bone of the fourth lumbar vertebrae(LV4)were examined with histomorphometrical analyses;the fifth lumbar vertebrae(LV5)were used to perform the compression test.Results Compared with the data from the sham-operated rats,the percent trabecular area,break stress and elastic modulus significantly decreased in OVX rats.Correspondingly,the bone break load decreased of post OVX was compared with those of sham-operated rats.Simvastatin increased the percent trabecular area compared with OVX rats,but it couldn’t meet the statistical significance.Simvastatin enhanced the break load and break stress compared with OVX rats.Conclusion Simvastatin can improve biomechanics of bone in aged ovariectomized osteopenia rats.更多还原