【摘要】 目的探讨表皮生长因子受体(epidermal growth factor receptor,EGFR)和转化生长因子-α(transforming growth factor-alpha,TGF-α)在非小细胞肺癌(non-small cell lung cancer,NSCLC)中的表达及其与临床病理特征的关系。方法采用免疫组织化学方法检测EGFR和TGF-α在66例NSCLC组织、10例肺正常组织中的表达情况,并分析两者的相关性及其与临床病理特征的关系。结果 EGFR和TGF-α在NSCLC组织中的阳性率分别为69.7%和71.2%,显著高于正常肺组织(30.0%和30.0%,P<0.05)。在NSCLC中,EGFR的高表达与分化程度、淋巴结转移及TNM分期密切相关(P<0.05);TGF-α的高表达与淋巴结转移及TNM分期密切相关(P<0.05)。EGFR与TGF-α两者表达呈正相关(P<0.05)。结论 TGF-α与EGFR在NSCLC中的表达均增高,两者表达具有相关性,可能在NSCLC的发生和发展中发挥重要作用,可为肺癌基因靶向治疗提供理论依据。更多还原

【Abstract】 Objective To investigate the expression of EGFR and TGF-α in non-small cell lung cancer(NSCLC),and explore its relationship with clinicopathologic features.Methods Immunohistochemistry method was used to examine the expressions of EGFR and TGF-α in 66 cases of NSCLC and 10 cases of normal lung tissue.The correlation between expression of EGFR and TGF-α and their relation with clinicopathological features were analyzed.Results The positive expression rate of EGFR and TGF-α were significantly higher in NSCLC than in normal lung tissue(69.7% vs 30.0% and 71.2% vs 30.0%,P<0.05).In NSCLC,the overexpression of EGFR had significant correlation with the differentiation dagree of cancer tissue,metastasis in lymph nodes and TNM stages(P<0.05).The overexpression of TGF-α has significant correlation with the metastasis in lymph nodes and TNM stages(P<0.05).EGFR and TGF-α expression showed positive correlation(P<0.05).Conclusion EGFR and TGF-α are overexpressed in NSCLC,and their expression is correleted.This suggests that EGFR and TGF-α may play an important role in the carcinogenesis and development of NSCLC,and this might be a potential therapeutic target for treatment of NSCLC.更多还原