【摘要】 目的评价多西他赛(希存,DOC)联合顺铂(DDP)、氟尿嘧啶(5-Fu)治疗晚期远处转移鼻咽癌的初步疗效及其毒副反应。方法治疗晚期远处转移鼻咽癌患者32例,给予DOC 75 mg/m2及DDP 75 mg/m2静脉滴注,第1天;5-Fu 500 mg/m2,第1～5天持续静脉灌注;每3周为1周期,所有患者均治疗2～4周期,观察毒副反应并评价化疗疗效。结果CR 5例(15.6%),PR 18例(56.3%),SD 7例(21.9%),PD 2例(6.3%)。总有效率72.0%。该方案最主要的毒副反应为骨髓抑制,Ⅲ～Ⅳ度粒细胞减少占68.8%;Ⅱ～Ⅲ度血小板下降占50.0%,其余毒副反应则可以耐受。结论多西他赛(希存)联合顺铂、氟尿嘧啶治疗晚期远处转移鼻咽癌的近期临床疗效较好,毒副反应可以耐受,值得临床推广。更多还原

【Abstract】 Objective To evaluate the efficacy and toxicity of docetaxel(Xicun) plus cisplatin and fluorouracil(TPF) regimen in the treatment of distant metastatic nasopharyngeal carcinoma.Methods Thirty-two patients with distant metastatic nasopharyngeal carcinoma were enrolled in this study.All cases were treated with docetaxel 75 mg/m2 plus cisplatin 75mg/m2 by intravenous drip on day 1,followed by fluorouracil 500mg/m2 as a continuous 24-hour infusion on days 1 to 5.Treatment was administered every 3 weeks for 2-4 cycles.Results The total effective rate was 72.0%.Five cases were complete response(15.6%),18 cases were partial response(56.3%),7 cases were stable disease(21.9%),2 cases were progressing disease(6.3%).The main adverse effect was myelosuppression,Ⅲ-Ⅳ grade neutropenia occurred in 68.8% of all cases,Ⅱ-Ⅲ grade thrombocytopenia was found in 50.0% of all cases,other adverse effects could be tolerated.Conclutions TPF regimen is a safe and effective therapy for patients with metastatic nasopharyngeal carcinoma.The toxic and adverse effects are tolerable,and the long effects deserve further evaluation.更多还原