【摘要】 目的:研究半枝莲黄酮(Scutellaria Barbata flavonoids,SBF)对去卵巢大鼠血脂变化的影响。方法:通过摘除雌性大鼠双侧卵巢模拟妇女绝经后体内血清雌激素水平降低和一系列代谢物质异常改变,观察半枝莲黄酮对血清中甘油三酯(TG),总胆固醇(TC),高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、动脉粥样硬化指数(AI=LDL-C/HDL-C)和冠心指数(R-CHD=TC/HDL-C)的影响;结合雌激素为阳性对照药。结果:与假手术组相比,去卵巢可使大鼠血脂代谢紊乱,血清中TG、LDL-C水平和心血管疾病危险因子AI和R-CHD皆显著增加(P<0.05,P<0.01),HDL-C含量显著降低(P<0.01),总胆固醇虽有升高但没有统计学意义。SBF可使去卵巢大鼠血脂代谢紊乱得到不同程度的改善,17.5,35,70mg.kg-1.d-1治疗5周可使血清中TG水平显著降低、HDL-C水平显著增加(P<0.05,P<0.01)和AI、R-CHD也显著降低(P<0.01);对血清TC和LDL-C具有不同的调节作用,但不具有统计学意义。阳性对照药结合雌激素对所有检测指标都有正向调节作用。结论:半枝莲黄酮能够改善去卵巢大鼠血脂紊乱,对动脉粥样硬化有一定的治疗作用。更多还原

【Abstract】 OBJECTIVE To investigate the effects of flavonoids from Scutellaria barbata on blood lipids in ovariectomized rats. METHODS The female rats were removed the both ovaries to imitate changes of postmenopausal women in serum estrogen and a series of metabolites. The effects of flavonoids from Scutellaria barbata on serum triglyceride (TG),total cholesterol (TC),high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C),atherosclerosis index (AI=LDL-C/HDL-C) and coronary index (R-CHD=TC/HDL-C) were observed. Conjugated estrogen was as a positive control. RESULTS Compared with the sham group,ovariectomized rats were in a state of lipid disorder. The levels of TG and LDL-C of serum and cardiovascular disease risk factors in AI and R-CHD were increased significantly (P<0.05,P<0.01),HDL-C was marked lowered (P<0.01) and TC was increased but significantly,respectively in ovariectomized rats. SBF can improve the blood lipid disturbances of ovariectomized rats in different degree. When the ovariectomized rats were treated with SBF 17.5,35 and 70 mg·kg-1·d-1 for consecutive five weeks,the serum TG content,AI and R-CHD were significantly lowered and the serum HDL-C level was noted increased (P<0.05,P<0.01),respectively. The three dose of SBF had different regulation with serum TC and LDL-C. And then,conjugated estrogen had an up-regulatory role in all hallmarks. CONCLUSION SBF can regulate the blood lipid disorders in ovariectomized rats and maybe have beneficial effect in atherosclerosis treatment.更多还原