【摘要】 目的:系统评价国内谷氨酰胺双肽增强的肠外营养对消化道肿瘤患者术后免疫功能的影响。方法:利用计算机检索中国生物医学文献数据库(2001-2009年)、中国期刊全文数据库(2001-2009年)及中文科技期刊全文数据库(2001-2009年),纳入谷氨酰胺肠外营养对于消化道肿瘤患者术后免疫功能影响的随机对照试验(RCT)文献,手工检索其他相关文献。对纳入的研究进行方法学质量评价,并采用RevMan5.0.20软件进行Meta分析。结果:共有6篇随机对照试验文献的研究符合纳入标准。Meta分析结果显示:术后一周,试验组患者各项免疫指标均有所恢复,其中IgG、IgM、IgA、CD4,以及CD4/CD8比值与对照组有非常显著性差异(P<0.01),CD3与对照组差异有显著性(P<0.05)。结论:含谷氨酰胺双肽的肠外营养可以改善和增强消化道肿瘤患者术后机体的免疫功能。更多还原

【Abstract】 OBJECTIVE To study the impact of the glutamine dipeptide parenteral nutrition on immufunction in the postoperative patients with gastrointestinal cancer.METHODS Randomized controlled trails(RCTs)were collected from CBMdisc(2001 to 2009),CNKI(2001 to 2009),and VIP(2001 to 2009).Other relevant journals were also hand searched.The methodological quality of included studies was evaluated,and data analyses were performed with The Cochrane Collaboration’s software RevMan 5.0.20.RESULTS Six prospective randomized controlled clinical trials(RCTs)met the criteria.Meta analysis showed that all the levels of immune function were restored on the eighth day after operation in experimental groups,and the levels of IgG,IgA,IgM,CD4 and CD4/CD8 were significantly different between two groups(P<0.01).CONCLUSION Parenteral nutrition supplemented with glutamine dipeptide can improve the immune function of patients with gastrointestinal cancer after operation.更多还原