【摘要】 目的:研究柳茶对D-半乳糖胺(D-GalN)肝损伤的保护作用及机制。方法:采用大鼠D-GalN急性肝损伤模型进行实验,检测大鼠血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、总蛋白、总胆红素、NO及肝甘油三酯、肝糖原、肝丙二醛含量。结果:柳茶(灌胃14～28g(生药).kg-1)能显著降低D-GalN肝损伤大鼠血清ALT、AST活性、总胆红素、NO含量及肝甘油三酯、肝丙二醛含量,提高血清总蛋白、肝糖原含量。结论:柳茶对D-GalN引起的大鼠急性肝损伤具有明显的保护作用,其机制可能与抑制自由基的产生、防止过度的脂质过氧化有关。更多还原

【Abstract】 OBJECTIVE To study the protective action of Liu Tea on D-galactosamine(D-GalN)induced acute liver injury in rats and its mechanism of action.METHODS The injured liver model induced by intraperitoneal injection of D-GalN was made in rats.The serum alanine aminotransferase(ALT),aspartate aminotransferase(AST)、total protein(TP),total bilirubin(TB),nitric oxide(NO),and liver triglycerides(TG)、glucogen(Gl)、malondiadehyde(MDA)were measured.RESULTS Liu Tea(ig,14.0-28.0 g·kg-1)inhibited the rise serum ALT,AST,TB,NO level and hepatic TG,MDA contents,and increased the contents of hepatic Gl and serum TP in D-GalN-intoxicated rats.CONCLUSION Liu Tea has protective action on D-GalN induced acute liver injury in rats.The mechanism of action of Liu Tea is related to the inhibition of free radicals production and lipid peroxidation.更多还原