【摘要】 目的:探讨冠心病患者经皮冠状动脉介入治疗术后血浆皮质抑素的变化及临床意义。方法:采用放射免疫方法测定40例冠心病(组)患者和40例正常对照(组)者的血浆皮质抑素,观察血浆皮质抑素水平在经皮冠状动脉介入治疗术前、术后的变化。结果:冠心病组(术前)血浆皮质抑素水平明显高于正常对照组[(2.63±0.48)ng/mlvs(1.18±0.27)ng/ml,P<0.01],差异有统计学意义。冠心病组支架置入术后第1天血浆皮质抑素水平接近术前[术后第1天(2.61±0.38)ng/mlvs术前(2.63±0.48)ng/ml,P>0.05]。术后第3天和第7天血浆皮质抑素水平分别为(2.42±0.45)ng/ml和(2.13±0.39)ng/ml,较术前分别降低8%和19%,差异均有统计学意义(P均<0.05)。多因素相关分析显示血浆皮质抑素与C反应蛋白呈正相关(R=0.88,P<0.05)。结论:冠心病患者血浆皮质抑素水平明显升高,冠心病患者支架置入术后血浆皮质抑素水平呈逐渐下降趋势。冠心病患者血浆皮质抑素水平的升高与反映炎症的指标C反应蛋白呈正相关。更多还原

【Abstract】 Objective:To investigate the alteration of plasma cortistatin level in patients with coronary heart disease(CHD)after percutaneous coronary intervention(PCI).Methods:There were 40 CHD patients after PCI(CHD group)and 40 healthy subjects(Control group)with the matched age enrolled in this study.Plasma cortistatin level was examined by radioimmunoassay in both groups before and after PCI procedure.Results:Plasma cortistatin level in CHD group was significantly higher than that in Control group(2.63±0.48)ng/ml vs.(1.18±0.27)ng/ml,P<0.01,before PCI.There was no significant difference of cotistatin level before PCI and 24 hr after PCI(2.61±0.38)ng/ml vs.(2.63±0.48)ng/ml,P>0.05,in CHD patients.While for CHD patients 3 days after PCI,cortistatin was(2.42±0.45)ng/ml as 8% deduction of the baseline,and 7 days after PCI,cortistatin was(2.13±0.39)ng/ml as 19% deduction of the baseline(P<0.05 respectively).Multivariate analysis revealed that plasma cortistatin level was positively correlated with C-reactive protein(CRP)(R=0.88,P<0.05).Conclusion:Plasma cortistatin increased markedly in CHD patients,the alteration of cortistatin concentration was positively correlated with CRP in CHD patients after PCI.更多还原