【摘要】 目的:观察颈椎退变动物模型中椎动脉血流及结构的变化。方法:将60只成年健康日本大耳白兔,随机分为两组,每组30只。实验组结扎并切断颈椎C4～5节段颈后肌群,然后切断C4～5节段的棘上及棘间韧带,同时行前路手术损伤C4～5前纵韧带和椎间盘结构;对照组仅切开显露并缝合颈部前后侧皮肤,切口长度与实验组相同,不做其他手术。术后第1、2、3个月彩色多普勒超声检测椎动脉搏动指数、阻力指数和血流量。术后第3个月,处死全部动物并取椎动脉标本,应用计算机图像分析系统测量椎动脉外径、内径、管壁厚度。结果:实验组椎动脉搏动指数、阻力指数和血流量在术后第1、2个月和对照组比较,差异无统计学意义(P>0.05);在术后第3个月和对照组比较,差异有统计学意义(P<0.05)。两组椎动脉外径比较,差异无统计学意义(P>0.05);两组椎动脉内径、壁厚比较,差异有统计学意义(P<0.05)。结论:颈椎退变的动物模型中椎动脉血流出现显著变化,椎动脉结构也出现异常。更多还原

【Abstract】 Objective:To observe the change of blood volume and structure of vertebral artery in animal model of cervical degeneration. Methods: 60 adult healthy Japanese white rabbits were randomly divided into the experimental group (n=30) and the control group (n=30). The experimental group were given transection of posterior muscles of neck and supraspinous and interspinous ligament at C4～5, and then were given destruction of anterior longitudinal ligament and intervertebral discs at C4～5 form anterior approach. The control group were given a shame operation. Pulsion index, resistence index and blood volume of vertebral artery were measured with Doppler ultrasound at 1, 2, 3 months after operation. All animal were sacrificed at 3 months and the vertebral arteries were picked up for pathology examination. External diameter,internal diameter and wall thickness of the vertebral arteries were measured with computer image analysis system. Results:There was no sig- nifcant difference in relative motion degree of Cand pulsion index, resistence index and blood volume of vertebral artery be - tween two groups at 1, 2 months after operation (P>0.05).There was signifcant difference in the above-mentioned indexes between two groups at 3 months after operation (P<0.05). There was no signifcant difference in external diameter of the vertebral arteries between two groups (P >0.05). There was signifcant difference in internal diameter and wall thickness of the vertebral arteries between two groups(P <0.05). Conclusion: Accompany with cervical degeneration, blood volume and structure of vertebral artery changed dramatically.更多还原