【摘要】 目的:研究洋金花(Datura metel L.)的化学成分。方法:采用 50%乙醇提取, 利用硅胶、Sephadex LH-20、ODS 柱层析和 HPLC 等方法进行分离和纯化, 依据核磁数据分析进行结构鉴定。结果:分离得到 9 个化合物, 分别鉴定为(+)松脂酚-O-β-D-双葡萄吡喃糖苷(1), (+)松脂酚-O-β-D-葡萄吡喃糖苷(2), 对羟基苯乙醇(3), N-p-香豆酰酪胺(4), 顺式-N-p-香豆酰酪胺(5), N-对羟基苯乙基-对羟基苯甲酰胺(6), 苯乙醇-O-β-D-葡萄吡喃糖基(2→1)-O-β-D-葡萄吡喃糖苷(7), 3-O-[β-D-葡萄吡喃糖基(1→2)]-β-D-半乳糖基-7-O-α-L-鼠李吡喃糖基-山柰酚(8), 3-O-[β-D-葡萄吡喃糖基(1→2)]-β-D-葡萄吡喃糖基-7-O-β-D-葡萄吡喃糖基-山柰酚(9)。结论:化合物 1～9 均为首次从该植物中分离得到。更多还原

【Abstract】 AIM: To study the chemical constituents of Datura metel L. METHODS: Extracted with 50% EtOH, the constituents were isolated and purified by silica gel, ODS and Sephadex LH-20 column chromatography as well as HPLC. Their chemical structures were elucidated on the basis of spectral data. RESULTS: Nine compounds were isolated and identified as (+)-pinoresinol-O-β-D-diglucopyranoside (1), (+)-pinoresinol-O-β-D-glucopyranoside (2), p-tyrosol (3), trans-N-p-coumaroyltyramine (4), cis-N-p-coumaroyltyramine (5), 4-hydroxy-N-(4-hydroxyphenethyl) benzamide (6), phenethyl alcohol-O-β-D-glucopyranosyl-(2→1)-O-β-D-glucopyranoside (7), kaempferol-3-O-β-D-glucopyranosyl-(1→2)-β-D-galactopyranosyl-7-O-α-L-rhamnopyranoside (8), and kaempferol-3-O-β-D-glucopyranosyl-(1→2)- β-D-galactopyranosyl-7-O-β-D-glucopyranoside (9). CONCLUSION: Compounds 1-9 have been isolated from this plant for the first time. [更多还原