【摘要】 目的观察血糖控制未达标2型糖尿病患者血糖波动与认知功能的关系。方法采用问卷调查的方法评定认知功能,比较不同血糖波动组间认知功能的差异,并对认知功能与问卷当日的血糖波动情况等进行相关性分析。结果 （1）日7次血糖的均数、标准差、血糖波动及总血糖在不同HbA₁c组间有统计学差异（P<0.01）;（2）不同血糖波动组间认知功能有统计学差异（P<0.05）,但性别、年龄、受教育年限等方面却无统计学差异（P>0.05）;（3）认知功能与检查当日7次血糖的平均值、最高血糖水平、最低血糖水平、血糖波动幅度及总血糖水平等均呈负相关。结论血糖控制未达标2型糖尿病患者认知功能与血糖波动密切相关。减少血糖波动对认知功能的保护有着重要的意义。更多还原

【Abstract】 Objective To study the relationship between the glucose fluctuation and the cognitive function in patients with bad-controlled type 2 diabetes mellitus （T2DM）.Methods Questionnaires were used to study cognitive function and to analyze the correlation of cognitive function and the levels of glucose fluctuation.Results （1）The mean,range and sum of the 7-point-daily capillary glucose showed differences with statistical significance between the HbA₁c≥8.5% and <8.5% groups（P<0.01）.（2） There were significant differences between the groups of glucose fluctuation ≥7.1mmol/L and < 7.1mmol/L,in the the delayed and clued body regions memory and the second auditory immediate memory （P<0.05）.Sex,age,educa’tional level,duration of diabetes,the level of systolic pressure and diastolic pressure,and HbA₁c had no difference between the two groups（P>0.05）.（3）Cognitive function showed a negative correlation with mean blood glucose（MBG,r=-0.185）,the highest and lowest glucose levels （r=-0.275,r=-0.236）,the range of glucose fluctuation （r=-0.287）,the sum of the 7-point-daily capillary glucose （r =-0.234）.Conclusions The glucose fluctuation has obvious correlation with cognitive function in bad-controlled T2DM patients.Controlling glucose effectively and reducing the glucose fluctuation will be beneficial for improving cognitive function.更多还原