【摘要】 目的探讨2型糖尿病患者白介素23（IL-23）、干扰素γ（IFN-γ）与胰岛素抵抗（IR）相关性。方法研究对象分为正常对照组（NGT）20例、新诊2型糖尿病组（DM1）33例、既往2型糖尿病组（DM2）32例,各组根据BMI又分为正常体重亚组（NW,BMI≤25kg/m²）、肥胖亚组（OB,BMI>25kg/m²）。检测各组的体重、身高、腰围、臀围、FPG、FIns、TC、TG、HbA₁c,酶免法测定IL-23、IFN-γ浓度,简易稳态模型评估胰岛素抵抗指数（HOMA IR）。结果 DM1、DM2组IL-23均较NGT组明显升高（P均<0.05）,DM1组较DM2组明显升高（P<0.01）,各组内NW和OB亚组间无统计学差异（P>0.05）;NGT、DM1、DM2三组间比较IFN-γ无统计学差异（P>0.05）。血清IL-23与HOMA-IR显著相关（r=0.412,P=0.001）,与IFN-γ无相关（P>0.05）;IFN-γ与HOMA-IR显著相关（r=0.739,P=0.001）。结论 2型糖尿病患者IL-23显著升高,与HOMA-IR显著相关,IFN-γ无明显升高,提示IL-23是2型糖尿病IR的重要细胞因子,IL-23不通过参与调节IFN-γ发挥作用。更多还原

【Abstract】 Objective To investigate the serum levels of interleukin～23 （IL-23） and interferon-γ （IFN-γ） with insulin resistance in patient with type 2 diabetes mellitus.Methods Ninety type 2 diabetics were divided into three groups of the normal glucose tolerance （NGT）,newly-diagnosed type 2 diabetes（DM1） and the previously diagnosed type 2 diabetes（DM2）.All the patients were then subdivided into NGT,DM1 and DM2 groups with normal weight and obesity.The weight,height,waist and hip circumference,fasting plasma glucose（FPG）,fasting insulin,total cholesterol,triglycerides and HbA₁c as well as serum IL-23 and IFN-γ were determined.Insulin resistance was calculated by the homeostasis model assessment （HOMA-IR）.Results Serum IL-23 levels in group DM1 and DM2 were increased compared with NGT group（P<0.05）,the IL-23 level in DM1 group was increased compared with DM2 group（P<0.01）,and there was no significant difference in IL-23 level between NW and OB subgroups of each group.There was no significant difference between any of DM1 and DM2 and NGT in IFN-γ level. IL-23 level correlated strongly with HOMA-IR（r=0.412,P=0.001）,was not correlate with IFN-γ（P> 0.05）.IFN-γ（r=0.739,P=0.001） was strongly associated with HOMA-IR.Conclusions Serum IL- 23 is significantly increased in type 2 diabetes mellitus,and strongly correlated with HOMA-IR.IFN-γ level shows no significant difference between group DM and NGT,indicating that IL-23 is an important mediator for insulin resistance in type 2 diabetes mellitus,producing a marked effect without adjusting IFN-γ.更多还原