【摘要】 目的探讨血清抵抗素水平与2型糖尿病(T2DM)视网膜病变(DR)的关系。方法将T2DM患者分为3组:单纯T2DM未合并DR组(DM组)95例、单纯型DR组(SDR组)62例和增殖型DR组(PDR组)30例。ELISA法检测187例T2DM患者血清抵抗素水平。结果 PDR组和SDR组血清抵抗素水平显著高于DM组(P<0.01或P<0.05);而且经校正性别、年龄和BMI后,PDR组抵抗素水平仍显著高于DM组(P<0.05)。Spearman相关性分析结果显示,DR患者血清抵抗素与BMI、SBP、空腹胰岛素和HOMA-IR呈显著性相关(P<0.05)。Logistic回归分析结果显示,血清抵抗素水平与PDR显著相关(OR=1.164,P<0.05)。结论血清抵抗素水平与DR相关,抵抗素可能参与DR尤其是PDR的发生与发展。更多还原

【Abstract】 Objective To investigate the relationship between serum resistin level and diabetic retinopathy (DR) in patients with type 2 diabetes.Methods Fasting serum resistin was measured with enzyme-linked immunosorbent assay (ELISA) in 187 patients with type 2 diabetes.The patients were divided into three groups:non-DR (DM) group (n=95),simple-DR (SDR) group (n=62),proliferative-DR (PDR) group (n=30).Results The fasting serum resistin level was significantly higher in SDR or PDR group that in DM group.(P<0.01 or P<0.05).After adjusting for age,sex and body mass index (BMI),the serum resistin level was still significantly higher in PDR group than in DM group (P = 0.041).Spearman analysis showed that serum resistin level in patients with DR was significantly correlated with BMI,SBP,fasting serum insulin and HOMA-IR (all P<0.05).Multivariate logistic regression analysis showed that serum resistin level was significantly associated with PDR(OR = l.164, P = 0.039).Conclusions Serum resistin concentration is related to DR in patients with type 2 diabetes, resistin may play a role in the development of DR,especially in the progress of PDR.更多还原